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Type 1 diabetes is it genetic

Our latest inclusion in the health report is the Type 1 Diabetes Genetic Risk Score, aimed at pinpointing individuals suitable for genetic testing for monogenic diabetes in cases where clinical features and autoimmune markers present ambiguity. This report offers autonomous insights for autoantibody and C-peptide testing, ensuring consistency as a DNA-based test, with results remaining constant over time.

Type 1 diabetes is a polygenic disease and common genetic variants have been identified that contribute to type 1 diabetes susceptibility. We genotype these variants and combine the risk of the individual variants that are present in a person to create a composite score that reflects an individual’s genetic susceptibility to type 1 diabetes.

On our website where you can easily upload raw DNA data file. This enables you to obtain a personalized health DNA report regarding T1D completely free of charge.

The likelihood of a patient having type 1 diabetes is based on the clinical information provided and the type 1 diabetes genetic risk score.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Type 1 diabetes and see a list of existing studies.

SNP polymorphisms related to the topic Type 1 diabetes:

rs689A break in the INS insulin gene associated with the occurrence of type 1 and type 2 diabetes.
rs229541A predisposition locus for type 1 diabetes and celiac disease.
rs237025The gene for ubiquitin-like modifier 4 (SUMO4) predisposition to type 1 diabetes.
rs425105Increased risk of islet autoimmunity and type 1 diabetes.
rs478582Increased risk of islet autoimmunity and type 1 diabetes.
rs725613Variation in the CLEC16A gene shows a consistent disease association with both multiple sclerosis and type 1 diabetes.
rs757411
rs763361rs763361, also known as Gly307Ser, is a SNP in the CD226 immune response gene. It is associated with an increased risk of multiple autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis.
rs917997
rs947474
rs1004446
rs1464510Common genetic variant in type 1 diabetes and celiac disease.
rs1465788Increased risk of islet autoimmunity and type 1 diabetes.
rs1701704Genetic variation associated with autoantibodies to insulin.
rs1738074Common genetic variant in type 1 diabetes and celiac disease.
rs1893217The PTPN2 risk gene is associated with Crohn's disease and type 1 diabetes.
rs1990760Associated with type 1 diabetes mellitus, organ-specific autoimmune diseases including Graves' disease.
rs2040410One of two polymorphisms (rs2040410 and rs7454108) that determine the highest risk of type 1 diabetes.
rs2069762
rs2069763Increased risk of autoimmune diseases - systemic lupus erythematosus, vasculitis, celiac disease, and newly diagnosed diabetes mellitus after transplantation.
rs2104286Genetic heterogeneity of IL2RA indicates susceptibility to multiple sclerosis and susceptibility to type 1 diabetes.
rs2290400increased risk of autoimmune diabetes in adults.
rs2292239The PTPN22 gene polymorphism associated with type 1 diabetes is related to the frequency of circulating regulatory T cells.
rs2296336
rs2476601This important SNP, located in the PTPN22 gene and also known as R620W or 1858C>T, may influence the risk of multiple autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, autoimmune thyroiditis and systemic lupus erythematosus.
rs25421512-fold risk of developing Crohn's disease and 1.6-fold for type 1 diabetes.
rs2544677
rs2639703
rs2664170Increased risk of islet autoimmunity and type 1 diabetes.
rs2816316Genetic variant risk for type 1 diabetes and gluten disease.
rs3024505Predisposition variants for ulcerative colitis, Crohn's disease and type 1 diabetes.
rs3087243The CTLA4 allelic variant alters T cell phosphorylation patterns and causes an increased risk of autoimmune diseases.
rs3129934
rs3184504A variant of celiac disease genetic risk associated with immune response. Also carrier associated type 1 diabetes.
rs3741208
rs3746722
rs3772534SNP rs3772534 in the CBLB gene indicates an increased risk of developing type 1 diabetes.
rs3788013A risk factor for islet autoimmunity and type 1 diabetes, as well as celiac disease, systemic lupus erythematosus and rheumatoid arthritis.
rs3825932Polymorphism of susceptibility to type 1 diabetes and celiac disease.
rs4763879Increased risk of islet autoimmunity and type 1 diabetes.
rs4788084Polymorphism of increased risk of adult autoimmune diabetes and diabetic retinopathy.
rs4900384Increased risk of islet autoimmunity and type 1 diabetes.
rs5753037Increased risk of islet autoimmunity and type 1 diabetes.
rs6441961Increased risk of gluten disease.
rs6679677An allelic variant of the PHTF1 gene is associated with a 5.2-fold increased risk of type 1 diabetes and a 3.3-fold increased risk of rheumatoid arthritis.
rs6822844Combined with the rs13119723 breakage, the study showed the strongest association with celiac disease among Caucasian patients.
rs6897932Variation in the IL7RA gene accounts for susceptibility to multiple sclerosis and type 1 diabetes.
rs7202877Increased risk of islet autoimmunity and type 1 diabetes.
rs7454108One of two polymorphisms (rs2040410 and rs7454108) that determine the highest risk of type 1 diabetes.
rs7528684
rs75748651.3-fold risk of rheumatoid arthritis
rs7804356Increased risk of islet autoimmunity and type 1 diabetes.
rs9272346HLA-DQA1 breakage is associated with a significant increase in risk (18-fold increase) of type 1 diabetes.
rs9388489Increased risk of islet autoimmunity and type 1 diabetes.
rs9811792
rs10517086Increased risk of islet autoimmunity and type 1 diabetes.
rs11052552
rs11171739Genetically dependent expression of ERBB3 modulates antigen-presenting cell function and risk of type 1 diabetes.
rs11571316Influences predisposition to diabetes and progression from prediabetes to diabetes in at-risk individuals.
rs11594656IL2RA gene polymorphism increases susceptibility to type I diabetes 1.19-fold for heterozygotes (AT) and 1.38-fold for homozygotes.
rs11755527Genetic predisposition between three autoimmune diseases: rheumatoid arthritis, type 1 diabetes and gluten disease.
rs12708716Polymorphisms influence the risk of developing type 1 diabetes.
rs12722495IL2RA gene polymorphism associated with type 1 diabetes.
rs17166496
rs17388568Genetic predisposition to insulin-dependent type 1 diabetes.
rs176967361.94-fold risk of insulin-dependent type 1 diabetes.
rs17810546Common genetic variant in type 1 diabetes and celiac disease.
rs41295061Genetic predisposition to type 1 diabetes and autoimmune thyroiditis.
rs45450798Polymorphisms affecting the disease process in type 1 diabetes and celiac disease.
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