SNP information rs1990760

Research and publications:

  16699517   A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

  17442111   The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.

  17535987   Genomic polymorphisms at the interferon-induced helicase (IFIH1) locus contribute to susceptibility to Graves' disease.

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  17940599   Assembly of inflammation-related genes for pathway-focused genetic analysis.

  18026693   The A946T polymorphism in the interferon-inducible helicase gene does not confer susceptibility to Graves' disease in the Chinese population.

  18071670   The association between the IFIH1 locus and type 1 diabetes.

  18285833   IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.

  18556337   Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)

  18647951   A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.

  18776148   Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms

  18840781   Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.

  18927125   IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.

  18987646   The expanding genetic overlap between multiple sclerosis and type I diabetes.

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19156166   IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.

  19251732   Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage.

  19264985   Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.

  19359276   Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  19430480   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

  19450885   Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1.

  19539001   IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.

  19732865   A generalized family-based association test for dichotomous traits.

  19838195   A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  19841890   The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.

  19951419   Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.

  19956101   Overview of the Rapid Response data

  19956106   Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

  19956109   Type I Diabetes Genetics Consortium Rapid Response Family-Based Candidate Gene Study: Strategy, Gene Selection, and Key Findings.

  19961590   The rs1990760 polymorphism in the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis, and Addison's disease.

  20018022   Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.

  20203524   Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk

  20392289   Genetic associations in type I interferon related pathways with autoimmunity.

  20467774   Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.

  20587799   Genetics of type 1 diabetes: what next?

  20644636   Study of transcriptional effects in Cis at the IFIH1 locus.

  20647273   Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

  20668468   Carriers of rare missense variants in IFIH1 are protected from psoriasis.

  20694011   Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20844740   Reduced expression of IFIH1 is protective for type 1 diabetes.

  20885991   Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  20953190   A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

  21055717   To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests.

  21270831   Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population.

  21594893   Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS).

  21705624   Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

  21826374   Selective IgA deficiency in autoimmune diseases.

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  21873553   Genetic analysis of adult-onset autoimmune diabetes.

  21980299   A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

  22046141   Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

  22053898   IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population.

  22110759   Polymorphisms in the innate immune IFIH1 gene, frequency of enterovirus in monthly fecal samples during infancy, and islet autoimmunity.

  22152027   Genetic variants in IFIH1 play opposite roles in the pathogenesis of psoriasis and chronic periodontitis.

  22187373   Why are C-section deliveries linked to childhood type 1 diabetes?

  22242199   Genetic factors of autoimmune thyroid diseases in Japanese.

  22315323   Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.

  22479352   The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.

  22536486   Lupus nephritis: an overview of recent findings.

  22640752   The genetics of lupus: a functional perspective.

  22654555   Genetic basis of Graves' disease.

  22753952   Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

  22770979   Presence of multiple independent effects in risk loci of common complex human diseases.

  22789000   Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.

  23036011   Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases.

  23108955   Association study of IFIH1 rs1990760 polymorphism with systemic lupus erythematosus in a Chinese population.

  23144876   Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

  23734776   Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis.

  23804261   From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.

  24653663   Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.

  24661571   Laying a strong foundation for Manhattan—“laying a functional foundation for the post-GWAS era.”

  24719229   Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.

  24949794   Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study.

  24960033   Association of innate immune IFIH1 gene polymorphisms with dilated cardiomyopathy in a Chinese population.

  25034154   Clinical perspectives on lupus genetics: advances and opportunities.

  25042601   Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families.

  25337792   Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population.

  25579795   The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25829454   Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.

  26074154   Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.

  26324017   Immunogenetics of systemic lupus erythematosus: A comprehensive review.

  26613086   Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.

  26678098   Association of interleukin-23 receptor gene polymorphisms with susceptibility to Crohn's disease: a meta-analysis.

  26904692   Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.

  27047537   Using Incomplete Trios to Boost Confidence in Family Based Association Studies.

  27716086   Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden.

  27810495   Psoriasis risk SNPs and their association with HIV-1 control.

  28000722   An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

  28553952   The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

  28929635   Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus.

  29070082   Sex influences eQTL effects in SLE and genetic polymorphisms associated with Sjögren's syndrome.

  29930297   Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients.

  29973096   Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.

  30171347   Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis.

  30327483   Phenome-wide association studies across large population cohorts support drug target validation.