SNP information rs6897932

Research and publications:

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  17660817   Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.

  17915034   Finding disease candidate genes by liquid association.

  17952073   Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

  18354419   IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.

  18461312   The immunogenetics of multiple sclerosis.

  18490360   The complex genetics of multiple sclerosis: pitfalls and prospects.

  18563381   Study of the association between the CAPSL-IL7R locus and type 1 diabetes.

  18565446   Refining genetic associations in multiple sclerosis.

  18650830   Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.

  18721276   The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis.

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  19010793   Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19221116   Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.

  19231135   Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients.

  19293837   Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.

  19359276   Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  19430480   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19525953   Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

  19546505   IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).

  19626040   Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

  19626041   Variation in IL7R predisposes to sarcoid inflammation.

  19744146   IL7RA polymorphisms and chronic inflammatory arthropathies.

  19865102   Multiple sclerosis susceptibility alleles in African Americans.

  19956108   Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

  20007504   Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.

  20072139   Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.

  20112030   Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.

  20182566   The genetic aspects of multiple sclerosis.

  20186855   What role for genetics in the prediction of multiple sclerosis?

  20194581   Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans.

  20219786   The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20362272   Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come.

  20368992   Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.

  20405052   The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

  20461788   Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients.

  20587799   Genetics of type 1 diabetes: what next?

  20662065   Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20885991   Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.

  20948966   Genome-wide data-mining of candidate human splice translational efficiency polymorphisms (STEPs) and an online database.

  20952449   Evaluation of the established non-MHC multiple sclerosis loci in an Indian population.

  21029420   The genetic basis of multiple sclerosis: a model for MS susceptibility.

  21161391   Association between the IL7R T244I polymorphism and multiple sclerosis: a meta-analysis.

  21244681   Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma.

  21247752   Revealing the genetic basis of multiple sclerosis: are we there yet?

  21280076   Aggregation of multiple sclerosis genetic risk variants in multiple and single case families.

  21287555   The interleukin-7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis.

  21333900   The role of genetics in IBS

  21543551   Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis.

  21629267   Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

  21826374   Selective IgA deficiency in autoimmune diseases.

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  21875636   Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination.

  21911588   IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?

  22021740   Systematic review of genome-wide expression studies in multiple sclerosis.

  22164203   Perspectives on the use of multiple sclerosis risk genes for prediction.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22262655   The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

  22396755   Genomic regions associated with multiple sclerosis are active in B cells.

  22492128   Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.

  22563461   HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.

  22654555   Genetic basis of Graves' disease.

  22936693   Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

  23094030   Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

  23454692   Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function.

  23462217   Polymorphisms in the interleukin-7 receptor α gene and mortality in untreated HIV-infected individuals.

  23692589   Polymorphism in the interleukin-7 receptor-alpha and outcome after allogeneic hematopoietic cell transplantation with matched unrelated donor.

  23730204   Progress in multiple sclerosis genetics.

  24033266   A systematic approach to assessing the clinical significance of genetic variants.

  24166352   The promoter SNP, but not the alternative splicing SNP, is linked to multiple sclerosis among Jordanian patients.

  24242875   Interleukin-7 receptor single nucleotide polymorphism rs6897932 (C/T) and the susceptibility to systemic lupus erythematosus.

  24337176   Association analysis of IL7R polymorphisms with inflammatory demyelinating diseases.

  24357513   The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population.

  24367383   Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young.

  24728327   Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.

  24770783   Genetic variants in IL2RA and IL7R affect multiple sclerosis disease risk and progression.

  24911352   Polymorphism in interleukin-7 receptor α gene is associated with faster CD4⁺ T-cell recovery after initiation of combination antiretroviral therapy.

  25061809   Analyzing genome-wide association studies with an FDR controlling modification of the Bayesian Information Criterion.

  25137520   Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions.

  25236396   Association between IL7RA polymorphisms and the successful therapy against HCV in HIV/HCV-coinfected patients.

  25421942   No association between rs6897932 in the gene encoding interleukin-7 receptor α and low-grade inflammation or self-reported health - results from the Danish Blood Donor Study.

  25690649   Multiple genetic variants associated with primary biliary cirrhosis in a Han Chinese population.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25903732   Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population.

  26123260   Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study.

  26402121   IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART.

  26904692   Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.

  27082982   P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART.

  27188999   Association between the IL7R T244I polymorphism and multiple sclerosis risk: a meta analysis.

  27802296   A Risk Score for Predicting Multiple Sclerosis.

  28082988   Investigating Factors Associated with Thymic Regeneration after Chemotherapy in Patients with Lymphoma.

  28139605   Analysis of the relationship between cytokine receptor gene polymorphisms and clinical features of multiple sclerosis.

  28181541   Gene variation in IL-7 receptor (IL-7R)α affects IL-7R response in CD4+ T cells in HIV-infected individuals.

  28582853   Investigating the exon 6 sequence changes of interleukin 7 receptor A (IL7RA) gene in patients with relapsing-remitting multiple sclerosis.