SNP information rs11594656

Research and publications:

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  17676041   Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

  18556337   Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)

  18776148   Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19106270   Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.

  19119414   IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

  19125193   IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

  19265545   Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.

  19701192   Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

  19956099   The type I diabetes association of the IL2RA locus.

  19956101   Overview of the Rapid Response data

  19956106   Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

  20033399   Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.

  20179739   Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.

  20236493   The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  21270278   An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.

  21629267   Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

  21815908   The Il2raâ/âCd25 gene variant, which predisposes to Graves' disease, is associated with increased levels of soluble interleukin-2 receptor.

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  21873553   Genetic analysis of adult-onset autoimmune diabetes.

  21952740   Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort.

  22085902   Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

  22110093   Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk.

  22211793   Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population.

  22328738   Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

  22479496   Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling.

  22654554   Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.

  23840476   Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.

  25347332   Interleukin-2 and its soluble receptor alpha subunit in autoimmune Addison's disease—an association study and expression analysis.

  26106387   Pathogenesis of Systemic Sclerosis.

  26133380   Associations of Independent IL2RA Gene Variants with Intermediate Uveitis.

  26249556   Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies.

  27288719   The association of PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms with T1D in Egyptian children.

  32319410   [Relationship between Single Nucleotide Polymorphisms of IL2RA, IL-10 Gene and Epstein-Barr Virus Associated Hemophagocytic Lymphohistiocytosisin in children].

  33178870   Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA , and HMGB1 Genes in Multiple Sclerosis.

  34031980   Polymorphisms and haplotypes of IL2RA, IL10, IFNG, IRF5, and CCR2 are associated with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children.