SNP information rs12708716

Research and publications:

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18252225   On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

  18423522   Estimating odds ratios in genome scans: an approximate conditional likelihood approach

  18533027   Worldwide population differentiation at disease-associated SNPs

  18556337   Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  18987646   The expanding genetic overlap between multiple sclerosis and type I diabetes.

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19140132   Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

  19359276   Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  19430480   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

  19639606   Correcting the “winner's curse” in odds ratios based on genome-wide association results for major complex human diseases.

  19734133   A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis.

  19838195   A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  19865102   Multiple sclerosis susceptibility alleles in African Americans.

  19951419   Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.

  20088021   Screen and clean: a tool for identifying interactions in genome-wide association studies.

  20182566   The genetic aspects of multiple sclerosis.

  20186855   What role for genetics in the prediction of multiple sclerosis?

  20362272   Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come.

  20369022   Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

  20405052   The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

  20587799   Genetics of type 1 diabetes: what next?

  20647273   Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20854658   Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.

  20885991   Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.

  21036813   A variable selection method for genome-wide association studies.

  21179112   Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.

  21266329   Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.

  21270831   Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population.

  21280076   Aggregation of multiple sclerosis genetic risk variants in multiple and single case families.

  21614020   The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus.

  21653641   Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.

  21765104   Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.

  21826374   Selective IgA deficiency in autoimmune diseases.

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  21873553   Genetic analysis of adult-onset autoimmune diabetes.

  21989056   Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.

  22046141   Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22257840   Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes.

  22496761   Improving power of genome-wide association studies with weighted false discovery rate control and prioritized subset analysis.

  22577522   Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis.

  22770979   Presence of multiple independent effects in risk loci of common complex human diseases.

  22778732   The Correlation between the CLEC16A Gene and Genetic Susceptibility to Type 1 Diabetes in Chinese Children.

  24646814   Polymorphisms of CLEC16A region and autoimmune thyroid diseases.

  26586731   In the loop: promoter-enhancer interactions and bioinformatics.

  26904692   Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.

  27153677   Assessing statistical significance in multivariable genome wide association analysis.

  30628751   Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  30970177   Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin-triggered type 1 diabetes.

  34799402   Alu insertion variants alter gene transcript levels.

  35432448   CLEC16A variants associated with autoimmune diseases confer risk for Parkinson's disease in Han Chinese.