SNP information rs2542151

Research and publications:

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18252225   On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

  18423522   Estimating odds ratios in genome scans: an approximate conditional likelihood approach

  18438406   Genetic determinants of ulcerative colitis include the ECM1 locus and five loci involved in Crohn's disease.

  18533027   Worldwide population differentiation at disease-associated SNPs

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  19140132   Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

  19359276   Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19565500   Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

  19639606   Correcting the “winner's curse” in odds ratios based on genome-wide association results for major complex human diseases.

  19776214   SimCT: a generic tool to visualize ontology-based relationships for biological objects

  19915572   Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

  19953089   Differences in genetic background between active smokers, passive smokers, and nonsmokers with Crohn's disease.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20369022   Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

  20403149   PTPN2, but not PTPN22, is associated with Crohn's disease in the New Zealand population.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20885991   Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.

  20923970   Bayesian epistasis association mapping via SNP imputation.

  20976797   P-value based analysis for shared controls design in genome-wide association studies.

  21217814   Presymptomatic risk assessment for chronic non-communicable diseases.

  21246196   A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21333900   The role of genetics in IBS

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21548950   Evaluation of 22 genetic variants with risk for Crohn's disease in an Ashkenazi Jewish population: a case-control study.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  21752155   Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.

  21818367   Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22021207   Crohn's disease-associated PTPN2 gene polymorphism affects muramyl dipeptide-induced cytokine secretion and autophagy.

  22426692   Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort.

  22457781   Variants in the PTPN2 gene are associated with susceptibility to both Crohn's disease and ulcerative colitis, supporting a common genetic basis for the disease.

  22654555   Genetic basis of Graves' disease.

  22984424   Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.

  23000205   Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23518806   Association between the PTPN2 gene and Crohn's disease: analysis of potential causative variants.

  23804260   Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.

  24127071   Association between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.

  24274136   Biobanking across the phenome - at the center of chronic disease research.

  25061809   Analyzing genome-wide association studies with an FDR controlling modification of the Bayesian Information Criterion.

  25369137   A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.

  25460303   Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.

  25652333   Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis.

  26344020   Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus.

  26734582   Genetic variations of PTPN2 and PTPN22: role in the pathogenesis of type 1 diabetes and Crohn's disease.

  26798662   Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype.

  26811645   Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.

  26833331   Retrospective Binary-Trait Association Test Elucidates Genetic Architecture of Crohn Disease.

  26865700   Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data.

  26928573   The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.

  26993061   Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

  27153677   Assessing statistical significance in multivariable genome wide association analysis.

  27331016   ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese.

  27336838   Blood and gut eQTLs from an anti-TNF-resistant Crohn's disease cohort inform genetic association loci for IBD.

  27342690   Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.

  27670835   Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease.

  27812365   Shared Genetic Etiology of Autoimmune Diseases in Patients from a Biorepository Linked to De-identified Electronic Health Records.

  27892471   Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies.

  29954342   LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  32807638   Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.

  34198814   Polymorphisms of the NOD2, IL23R, PTPN2 and ATG16L1 genes in patients with Crohn's disease: towards personalized medicine?