SNP information rs6822844

Research and publications:

  17558408   A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

  17999365   Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.

  18311140   Newly identified genetic risk variants for celiac disease related to the immune response.

  18369459   A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

  18418394   Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.

  18713140   Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

  18794853   Common variants at CD40 and other loci confer risk of rheumatoid arthritis

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19176549   Genome-wide association analysis by lasso penalized logistic regression.

  19180477   Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations

  19201773   Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.

  19248117   Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis.

  19302705   Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.

  19359276   Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  19404967   Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis.

  19455118   Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19471255   Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease.

  19523143   Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population.

  19546505   IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).

  19648293   Replication of celiac disease UK genome-wide association study results in a US population.

  19898481   Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

  20072139   Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.

  20075733   Recent advances in the genetics of rheumatoid arthritis.

  20112382   Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.

  20179739   Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.

  20184734   The 4q27 locus and prostate cancer risk.

  20219786   The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

  20233754   Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.

  20309874   Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

  20444755   Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

  20445516   Consolidating evidence linking the KIAA1109-TENR-IL2-IL21 rs6822844 variant to Crohn's disease.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20461788   Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients.

  20498205   Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.

  20510233   Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

  20553587   Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  21120996   Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.

  21211616   Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.

  21304239   Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis.

  21375519   A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.

  21383967   Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

  21425124   Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.

  21425313   Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.

  21760890   Potential celiac patients: a model of celiac disease pathogenesis.

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  21875375   Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.

  21931699   Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.

  22087237   Improving the estimation of celiac disease sibling risk by non-HLA genes.

  22174698   A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.

  22328738   Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

  22355377   Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians.

  22577522   Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis.

  22654555   Genetic basis of Graves' disease.

  22661644   Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

  22984424   Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.

  23000205   Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.

  23121884   Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease.

  23172754   Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.

  23251581   Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades.

  23645042   IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients.

  24068971   Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.

  24154763   Polymorphic variant at the IL2 region is associated with type 1 diabetes and may affect serum levels of interleukin-2.

  24281113   Inflammatory genetic markers of prostate cancer risk.

  24449572   Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

  25037274   Autoimmune diseases association study with the KIAA1109-IL2-IL21 region in a Tunisian population.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25328554   Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.

  25347332   Interleukin-2 and its soluble receptor alpha subunit in autoimmune Addison's disease—an association study and expression analysis.

  25377634   IL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation.

  26106387   Pathogenesis of Systemic Sclerosis.

  26413272   Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine.

  26613086   Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.

  27274049   Early farmers from across Europe directly descended from Neolithic Aegeans.

  28883856   Interleukin-21 gene polymorphism rs2221903 is associated with disease activity in patients with rheumatoid arthritis.

  30206443   Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future.

  30842160   The Influence of Single Nucleotide Polymorphisms and Adjuvant Radiotherapy on Systemic Inflammatory Proteins, Chemokines and Cytokines of Patients With Breast Cancer.

  31366568   Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility.

  31454755   IL-17, IL-21 and IL-22 polymorphisms in rheumatoid arthritis: A systematic review and meta-analysis.

  31519598   Genetic Variants of the IL2 Gene Related to Risk and Survival in Patients With Colorectal Cancer.

  31763680   IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility.

  33673829   Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis.