SNP information rs917997

Research and publications:

  18311140   Newly identified genetic risk variants for celiac disease related to the immune response.

  18439550   Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  18713140   Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

  19068216   Investigation of Crohn's disease risk loci in ulcerative colitis further determines their molecular relatedness.

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19103669   Association study of the IL18RAP locus in three European populations with coeliac disease.

  19430480   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19557189   Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

  19648293   Replication of celiac disease UK genome-wide association study results in a US population.

  19693089   Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.

  19915574   Common variants at five new loci associated with early-onset inflammatory bowel disease.

  20176734   Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.

  20190752   Multiple common variants for celiac disease influencing immune gene expression.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20353565   Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

  20560212   Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20587799   Genetics of type 1 diabetes: what next?

  20647273   Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20854658   Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.

  21150878   Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21629437   Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases.

  21682861   Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.

  21760890   Potential celiac patients: a model of celiac disease pathogenesis.

  21826374   Selective IgA deficiency in autoimmune diseases.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22315323   Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.

  22550553   An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration.

  22664470   Interleukin-18 pathway genes are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma.

  24337767   A candidate single nucleotide polymorphism predicts failure to respond to first anti-TNF inhibitor treatment in ankylosing spondylitis.

  24621393   Genetic polymorphisms in the IL-18 gene and ulcerative colitis risk: a meta-analysis.

  24842757   The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.

  24909718   Analysis of the association of polymorphic loci rs917997 in the IL18RAP gene and rs187238 in the IL18 gene with the risk of developing non-Hodgkin malignant lymphomas in the Novosibirsk population.

  25980667   Pharmacogenetics of treatment response in psoriatic arthritis.

  26229413   Genetic polymorphisms of interleukin-18 have different effects on susceptibility to Crohn's disease.

  26281980   Age and pro-inflammatory gene polymorphisms influence adjacent segment disc degeneration more than fusion does in patients treated for chronic low back pain.

  26289103   Systematic review and meta-analysis of the association between IL18RAP rs917997 and CCR3 rs6441961 polymorphisms with celiac disease risks.

  26358252   Association of genetic polymorphisms of interleukins with gastric cancer and precancerous gastric lesions in a high-risk Chinese population.

  26445852   Genetic biomarkers of susceptibility and progression of Barrett's esophagus to dysplasia and cancer: a systematic review and meta-analysis.

  26566691   Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.

  26893844   Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer.

  26904692   Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27536357   Genetic predisposition to Barrett's esophagus: lessons from early research.

  27863251   Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

  29285382   IL18 rs360719 A>G, IL18R1 rs13015714 G>T, IL18RAP rs917997 C>T and IL28B rs8099917 T>G polymorphisms and risk of gastric cardiac adenocarcinoma.

  31126849   Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population.

  31147177   IL18RAP polymorphisms and its plasma levels in patients with Lumbar disc degeneration.

  32284404   The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA.

  33262486   Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

  33522333   IL18-family Genes Polymorphism Is Associated with the Risk of Myocardial Infarction and IL18 Concentration in Patients with Coronary Artery Disease.