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SNP information rs7454108

Normal allele: TT

One of two polymorphisms (rs2040410 and rs7454108) that determine the highest risk of type 1 diabetes.

Polymorphism rs7454108 is related to topics like this:

Type 1 diabetes

Research and publications:

  15747258   A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.

  18509540   Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.

  18694972   Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening.

  19143815   MHC fine mapping of human type 1 diabetes using the T1DGC data.

  19143817   Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.

  19455305   No association of multiple type 2 diabetes loci with type 1 diabetes

  19458622   Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.

  20398668   Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study.

  21266329   Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.

  22511809   Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.

  24876751   Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients.

  24943594   Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.

  25829454   Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.

  27449795   Shared and unique common genetic determinants between pediatric and adult celiac disease.

  28056976   A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

  29857070   Association Study and Fine-Mapping Major Histocompatibility Complex Analysis of Pemphigus Vulgaris in a Han Chinese Population.

  31342641   Single-nucleotide polymorphisms associated with pemphigus vulgaris: Potent markers for better treatment and personalized medicine.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  34172490   The High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Polymorphisms Are Differentially Associated With Growth and IGF-I Levels in Infancy: The Cambridge Baby Growth Study.