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SNP information rs689

Normal allele: AA

A break in the INS insulin gene associated with the occurrence of type 1 and type 2 diabetes.

Polymorphism rs689 is related to topics like this:

Type 1 diabetes is it genetic

Our latest inclusion in the health report is the Type 1 Diabetes Genetic Risk Score, aimed at...

The gene known as INSR directs the production of insulin receptors - proteins present in various...

Research and publications:

  16595598   The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.

  17334650   A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene

  17554260   Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

  17606874   Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes

  17667841   Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.

  17683561   The TCF7L2 locus and type 1 diabetes

  18252225   On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

  18292987   Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes

  18310307   Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes

  18375961   Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.

  18556337   Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)

  18940880   Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese.

  19020323   Genotype score in addition to common risk factors for prediction of type 2 diabetes

  19073967   Shared and distinct genetic variants in type 1 diabetes and celiac disease

  19168599   Type 1 diabetes in the BB rat: a polygenic disease.

  19188433   Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

  19434426   Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth.

  19833889   Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study

  19956106   Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

  20144318   A strategy for analyzing gene-nutrient interactions in type 2 diabetes.

  20647273   Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20805278   Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.

  20854658   Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.

  20889853   Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

  21121051   The reference human genome demonstrates high risk of type 1 diabetes and other disorders.

  21266329   Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21407270   Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.

  21424820   Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21829393   Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

  21873553   Genetic analysis of adult-onset autoimmune diabetes.

  22315323   Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.

  22511809   Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.

  22666415   Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.

  23056239   Handling missing data in transmission disequilibrium test in nuclear families with one affected offspring.

  23721563   Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies.

  23835325   Patterns of β-cell autoantibody appearance and genetic associations during the first years of life.

  24275212   The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia.

  24367383   Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young.

  24719615   Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.

  24875393   A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes.

  24944197   Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex.

  25557790   An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women.

  25951190   Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology.

  25964488   GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.

  26074154   Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.

  26251103   Association of genetic variants in INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) with type 2 diabetes (T2D): a case-control study in three ethnic groups from North-West India.

  26273670   The Genetic Profile from HLA and Non-HLA Loci Allows Identification of Atypical Type 2 Diabetes Patients.

  26904692   Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.

  26907721   Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.

  27331016   ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese.

  27352912   Variants associated with autoimmune Type 1 diabetes in Japanese children: implications for age-specific effects of cis-regulatory haplotypes at 17q12-q21.

  27667266   Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas.

  28646072   Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.

  28652652   Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.

  29343548   Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

  30456822   Association of common type 1 and type 2 diabetes gene variants with latent autoimmune diabetes in adults: A meta-analysis.

  31150930   Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1.

  31211453   Association of metabolism-related genes polymorphisms with adenocarcinoma of the oesophagogastric junction: Evidence from 2261 subjects.

  31808541   Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.

  32061050   DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.

  34362956   Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients.

  35742925   Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus.

  36034444   Genetics: Is LADA just late onset type 1 diabetes?

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