Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Insulin and see a list of existing studies.
SNP polymorphisms related to the topic Insulin:
|A break in the INS insulin gene associated with the occurrence of type 1 and type 2 diabetes.
|Genetic polymorphisms involved in the insulin-like growth factor (IGF) pathway regulate mammographic breast density ratio.
|The GCKR rs780094 polymorphism is associated with increased fasting serum triacylglycerol, decreased fasting insulinaemia and reduced risk of type 2 diabetes. A diet restricting carbohydrates and increasing protein is particularly effective for carriers of the T risk allele.
|A polymorphism (K121Q) of the region encoding human glycoprotein PC-1 is closely associated with insulin resistance.
|HHEX gene polymorphism is associated with impaired proinsulin conversion and increased risk of developing type 2 diabetes.
|Variation in the HNF1A gene region affects CRP levels. The association between the common variant of the HNF1A gene p.I27L (rs1169288) and the risk of developing type 2 diabetes mellitus is weight-dependent.
|Widespread amino acid polymorphism is associated with insulin resistance and insulin hypersecretion.
|The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. It also causes impaired insulin signalling and affects glucose metabolism in skeletal muscle cells.
|Peroxisome proliferator-activated receptor gamma gene variation on the progression of type 2 diabetes and obesity. Also higher risk of cardiovascular disease with a diet high in saturated fat.
|Polymorphisms in the insulin-degrading enzyme (IDE) gene determine insulin metabolism and the risk of developing type 2 diabetes. It also affects a person's life expectancy.
|The insulin receptor variant is associated with insulin resistance and polycystic ovary syndrome.
|Insulin-like growth factor 1 (IGF-1) receptor polymorphic variant correlates with male longevity.
|Growing role of TRIB3 as a gene affecting human insulin resistance on glucose homeostasis by altering the interaction between insulin sensitivity and secretion.
|Genetic predisposition to long-term non-diabetic disorders of glucose homeostasis.
|Increased risk of islet autoimmunity and type 1 diabetes.
|The single nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion and proinsulin conversion.
|This is one of two SNPs in the TCF7L2 gene that have been reported to be strongly associated with type 2 diabetes, the other being rs4506565. They have approximately equal power to assess the risk of developing type 2 diabetes , and the results of one test correlate with the other in 92% of cases. Associated with reduced insulin secretion, as measured by the acute response to insulin and increased rate of glucose production in the liver.
|Determinants of B-cell function and fasting glycaemic trajectories in childhood.
|common variant MTNR1B, which encodes melatonin receptor 1B, increases the risk of impaired fasting glycaemia and type 2 diabetes due to impaired glucose-stimulated insulin release. The findings suggest that carriers of the G allele rs10830963 may have greater improvement in obesity and body fat distribution when following a low-fat diet.
|Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with a significant increase in the risk of type 2 diabetes.
|The zinc transporter gene SLC30A8 polymorphism is associated with type 2 diabetes.