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Insulin DNA health report

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Insulin and see a list of existing studies.

SNP polymorphisms related to the topic Insulin:

rs689A break in the INS insulin gene associated with the occurrence of type 1 and type 2 diabetes.
rs6220Genetic polymorphisms involved in the insulin-like growth factor (IGF) pathway regulate mammographic breast density ratio.
rs30360
rs484659
rs487894
rs634264
rs780094The GCKR rs780094 polymorphism is associated with increased fasting serum triacylglycerol, decreased fasting insulinaemia and reduced risk of type 2 diabetes. A diet restricting carbohydrates and increasing protein is particularly effective for carriers of the T risk allele.
rs816200
rs891088
rs1004361
rs1044498A polymorphism (K121Q) of the region encoding human glycoprotein PC-1 is closely associated with insulin resistance.
rs1111875HHEX gene polymorphism is associated with impaired proinsulin conversion and increased risk of developing type 2 diabetes.
rs1169288Variation in the HNF1A gene region affects CRP levels. The association between the common variant of the HNF1A gene p.I27L (rs1169288) and the risk of developing type 2 diabetes mellitus is weight-dependent.
rs1400589
rs1501635
rs1517204
rs1799999Widespread amino acid polymorphism is associated with insulin resistance and insulin hypersecretion.
rs1801278The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. It also causes impaired insulin signalling and affects glucose metabolism in skeletal muscle cells.
rs1801282Peroxisome proliferator-activated receptor gamma gene variation on the progression of type 2 diabetes and obesity. Also higher risk of cardiovascular disease with a diet high in saturated fat.
rs1887922Polymorphisms in the insulin-degrading enzyme (IDE) gene determine insulin metabolism and the risk of developing type 2 diabetes. It also affects a person's life expectancy.
rs2059807The insulin receptor variant is associated with insulin resistance and polycystic ovary syndrome.
rs2229765Insulin-like growth factor 1 (IGF-1) receptor polymorphic variant correlates with male longevity.
rs2295490Growing role of TRIB3 as a gene affecting human insulin resistance on glucose homeostasis by altering the interaction between insulin sensitivity and secretion.
rs4304868
rs4492895
rs4607103Genetic predisposition to long-term non-diabetic disorders of glucose homeostasis.
rs4698790
rs7202877Increased risk of islet autoimmunity and type 1 diabetes.
rs7254487
rs7254921
rs7255710
rs7342408
rs7754840The single nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion and proinsulin conversion.
rs7903146This is one of two SNPs in the TCF7L2 gene that have been reported to be strongly associated with type 2 diabetes, the other being rs4506565. They have approximately equal power to assess the risk of developing type 2 diabetes , and the results of one test correlate with the other in 92% of cases. Associated with reduced insulin secretion, as measured by the acute response to insulin and increased rate of glucose production in the liver.
rs7964607
rs7976621
rs7977174
rs9787485Determinants of B-cell function and fasting glycaemic trajectories in childhood.
rs10431397
rs10744901
rs10774926
rs10830963common variant MTNR1B, which encodes melatonin receptor 1B, increases the risk of impaired fasting glycaemia and type 2 diabetes due to impaired glucose-stimulated insulin release. The findings suggest that carriers of the G allele rs10830963 may have greater improvement in obesity and body fat distribution when following a low-fat diet.
rs12255372Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with a significant increase in the risk of type 2 diabetes.
rs12425296
rs13266634The zinc transporter gene SLC30A8 polymorphism is associated with type 2 diabetes.
rs16891077
rs17619048
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