SNP information rs1169288

Research and publications:

  12453420   Diabetes mutations delineate an atypical POU domain in HNF-1alpha.

  12788852   Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.

  18332101   Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

  18439552   Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

  18498634   The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19490620   HNF1A gene polymorphisms and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional study.

  20031592   Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Car

  20416077   Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

  21094359   Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily).

  21195701   Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese.

  21498636   Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.

  21647738   Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  21862702   Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

  21918647   Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver

  21937998   Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults.

  21998633   Functional evaluation of genetic and environmental regulators of p450 mRNA levels.

  22010049   Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.

  22529894   Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.

  22569176   MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.

  24062323   Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes.

  24309190   Genetics of new-onset diabetes after transplantation.

  24365473   An association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretation.

  24728327   Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.

  24933231   Associations between the common HNF1A gene variant p.I27L (rs1169288) and risk of type 2 diabetes mellitus are influenced by weight.

  25050552   A systematic evaluation of short tandem repeats in lipid candidate genes: riding on the SNP-wave.

  25302496   Using multivariable Mendelian randomization to disentangle the causal effects of lipid fractions.

  25376095   Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  26174136   Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.

  26209006   Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population.

  26293461   Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

  26977395   Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.

  27035118   Whole-genome re-sequencing for the identification of high contribution susceptibility gene variants in patients with type 2 diabetes.

  27051588   Analysis of single nucleotide polymorphisms implicate mTOR signalling in the development of new-onset diabetes after transplantation.

  28035729   Association of the HNF1A polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke.

  28577571   Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.

  28712822   Association study of HNF1A polymorphisms with metabolic syndrome in the Moroccan population.

  28834135   The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial.

  29303622   Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers.

  29403300   Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression.

  29895593   The Common HNF1A Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY.

  31109344   HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey.

  31114636   Maternal genetic contribution to pre-pregnancy obesity, gestational weight gain, and gestational diabetes mellitus.

  31584351   Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study.

  31915469   Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients.

  32375679   Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion.

  33363396   Incidence of HNF1A and GCK MODY Variants in a South African Population.

  34253456   Variants in mycophenolate and CMV antiviral drug pharmacokinetic and pharmacodynamic genes and leukopenia in heart transplant recipients.

  35673428   Meta-analysis of HNF1A-MODY3 variants among human population.