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SNP information rs1801282

Normal allele: CC

Peroxisome proliferator-activated receptor gamma gene variation on the progression of type 2 diabetes and obesity. Also higher risk of cardiovascular disease with a diet high in saturated fat.

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Research and publications:

  9792554   Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations

  16713673   Variations in the peroxisome proliferator-activated receptor-gamma gene and melanoma risk

  16783862   PPAR-gamma gene polymorphisms and psoriatic arthritis

  17094261   Effect of the peroxisome proliferators-activated receptor (PPAR) gamma 3 gene on BMI in 1,210 school students from Morelos, Mexico

  17187763   Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function

  17213274   Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone

  17348446   Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer

  17355643   Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population

  17570749   Genetic prediction of future type 2 diabetes

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  17825092   Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

  17903291   The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

  17903298   Genome-wide association with diabetes-related traits in the Framingham Heart Study

  17903300   Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project

  18091023   SNPs in PPARG associate with type 2 diabetes and interact with physical activity

  18160840   The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma gene with serum osteoprotegerin levels in healthy Korean women

  18162508   Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18280041   PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes

  18282109   Adaptations to climate in candidate genes for common metabolic disorders

  18288282   Genetic polymorphisms of peroxisome proliferator-activated receptors and the risk of cardiovascular morbidity and mortality in a community-based cohort in washington county, Maryland

  18304332   No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins

  18319073   Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes

  18340007   Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia

  18372903   Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

  18401448   PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease

  18426861   Association analysis of type 2 diabetes Loci in type 1 diabetes

  18426866   Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

  18498634   The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18533027   Worldwide population differentiation at disease-associated SNPs

  18591388   Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

  18598350   Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18678618   Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes

  18689899   Exchangeable models of complex inherited diseases

  18694974   Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

  18707223   PPARG by dietary fat interaction influences bone mass in mice and humans

  18782870   Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008

  18787887   Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures

  18805939   Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis

  18806092   Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin

  18852197   Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  18959602   The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals

  18972257   Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study

  18992148   Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

  18992263   Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways

  18996470   Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes

  19002430   Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

  19020323   Genotype score in addition to common risk factors for prediction of type 2 diabetes

  19056611   Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19161620   An open access database of genome-wide association results

  19178525   PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population

  19207020   Meta-analysis in genome-wide association studies

  19228871   PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19279076   Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men

  19323962   Genome-wide association studies in type 2 diabetes

  19324937   Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults

  19341491   Genome-based prediction of common diseases: methodological considerations for future research

  19360113   The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy

  19401414   Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population

  19455305   No association of multiple type 2 diabetes loci with type 1 diabetes

  19460916   Genetic architecture of type 2 diabetes: recent progress and clinical implications

  19502414   Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men

  19526209   Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

  19543210   PPARG genotype accounts for part of individual variation in body weight reduction in response to calorie restriction

  19567509   Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes

  19587357   A systematic meta-analysis of genetic association studies for diabetic retinopathy

  19602701   Underlying genetic models of inheritance in established type 2 diabetes associations

  19603096   An analysis of growth, differentiation and apoptosis genes with risk of renal cancer

  19626703   Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies

  19634985   Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and risk for pediatric obesity

  19644638   No association between polymorphisms of peroxisome [corrected] proliferator-activated receptor-gamma gene and peak bone mineral density variation in Chinese nuclear families

  19720797   Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT

  19733160   Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population

  19734549   Ranking of genome-wide association scan signals by different measures

  19745552   Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status

  19773451   Role of inflammation gene polymorphisms on pain severity in lung cancer patients

  19794065   Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes

  19846176   PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor

  19862325   PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population

  19931040   Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies

  19956539   How many genetic variants remain to be discovered?

  20017978   Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study

  20018041   The effect of multiple genetic variants in predicting the risk of type 2 diabetes

  20018066   Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study

  20043145   Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

  20043853   Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

  20049090   Association between type 2 diabetes loci and measures of fatness

  20075150   Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

  20079163   Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population

  20142250   Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study

  20144327   A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel

  20161779   Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

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