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Type 2 diabetes DNA health report

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Type 2 diabetes and see a list of existing studies.

SNP polymorphisms related to the topic Type 2 diabetes:

rs5215A common genetic variant with moderate effect of predisposition to type 2 diabetes and obesity.
rs5219The E23K variant of the Kir6.2 gene is associated with impaired serum insulin response and an increased risk of developing type 2 diabetes.
rs7636
rs163184
rs231362
rs243021
rs358806
rs3913001.86 times higher risk of developing gestational diabetes.
rs472265
rs515071
rs642858
rs649891
rs741301A variant intron 13 of the ELMO1 gene is associated with diabetic nephropathy.
rs791595
rs831571
rs849134
rs864745A single nucleotide polymorphism in the JAZF1 gene is nominally associated with type 2 diabetes.
rs896854
rs972283
rs997509
rs1048886
rs1111875HHEX gene polymorphism is associated with impaired proinsulin conversion and increased risk of developing type 2 diabetes.
rs1387153The MTNR1B variant is associated with elevated fasting plasma glucose levels and risk of type 2 diabetes.
rs1423096
rs1470579A new risk locus for the development of type 2 diabetes.
rs1495377
rs1531343
rs1799999Widespread amino acid polymorphism is associated with insulin resistance and insulin hypersecretion.
rs1801282Peroxisome proliferator-activated receptor gamma gene variation on the progression of type 2 diabetes and obesity. Also higher risk of cardiovascular disease with a diet high in saturated fat.
rs1861612
rs1889018
rs2028299
rs2106294
rs2236513
rs2237892Genetic variability in KCNQ1 is associated with fasting glucose levels and beta-cell function.
rs2237897A common variant in the KCNQ1 gene cause an increased risk of developing type 2 diabetes and contribute to the diabetes epidemic.
rs2283228A common variant in the KCNQ1 gene cause an increased risk of developing type 2 diabetes and contribute to the diabetes epidemic.
rs2289116
rs2295490Growing role of TRIB3 as a gene affecting human insulin resistance on glucose homeostasis by altering the interaction between insulin sensitivity and secretion.
rs2297508Association of sterol regulatory element binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels.
rs2383208
rs2903265
rs2930291
rs3745367RETN resistin polymorphism is associated with obesity and increases susceptibility to type 2 diabetes mellitus.
rs3786897
rs3792615
rs3802177
rs3923113
rs4402960Locus of risk for developing type 2 diabetes as well as increased risk for gestational diabetes.
rs4430796A common genetic risk variant for type 2 diabetes and prostate cancer.
rs4457053
rs4506565A common variant of the TCF7L2 gene is closely associated with type 2 diabetes mellitus.
rs4527850
rs4607103Genetic predisposition to long-term non-diabetic disorders of glucose homeostasis.
rs4655595
rs4712523CDKAL1 deletion affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion, suggesting a link to diabetes.
rs4760790
rs4812829Polymorphisms have demonstrated a strong association with increased susceptibility to type 2 diabetes.
rs5015480Genetic variants associated with type 2 diabetes found in recent whole-genome association studies are also associated with gestational diabetes mellitus.
rs6426514
rs6502618
rs6712932
rs6718526
rs6769511
rs6815464
rs6930576
rs7018475
rs7041847
rs7172432
rs7178572
rs7305618
rs7403531
rs7560163
rs7578326
rs7578597A novel type 2 diabetes risk allele at the THADA locus.
rs7593730
rs7630877
rs7659604
rs7754840The single nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion and proinsulin conversion.
rs7756992A new risk locus for the development of type 2 diabetes.
rs7901695The TCF7L2 gene polymorphism confers an increased risk of early impaired glucose metabolism, impaired insulin secretion induced by glucagon-like peptide-1.
rs7903146This is one of two SNPs in the TCF7L2 gene that have been reported to be strongly associated with type 2 diabetes, the other being rs4506565. They have approximately equal power to assess the risk of developing type 2 diabetes , and the results of one test correlate with the other in 92% of cases. Associated with reduced insulin secretion, as measured by the acute response to insulin and increased rate of glucose production in the liver.
rs7923837Variations in the HHEX gene are associated with an increased risk of developing type 2 diabetes, affects acute glucose-stimulated insulin release.
rs7961581Associated with type 2 diabetes, linked to insulin resistance in offspring of patients with type 2 diabetes.
rs8042680
rs8050136Obesity-related heterogeneity in models of predisposition to type 2 diabetes.
rs8090011
rs9300039
rs9326506
rs9465871A common variant in the CDKAL1 gene is associated with type 2 diabetes and impaired fasting glucose levels.
rs9470794
rs9472138
rs9552911
rs9939609The common variant rs9939609 of the FTO gene, associated with fat mass and obesity, is associated with fat cell lipolysis as well as early onset of extreme obesity. Studies show that carriers of the risk allele A demonstrate significantly greater weight loss on a fat-restricted diet than non-carriers.
rs10229583The rs10229583 polymorphism near the paired PAX4 gene is associated with gestational diabetes mellitus in women.
rs10440833
rs10461617
rs10811661The polymorphism is associated with impaired proinsulin conversion and redisposition to type 2 diabetes.
rs10814916
rs10886471The GRK5 variant is associated with the efficacy of repaglinide in patients with type 2 diabetes mellitus.
rs10906115
rs10946398A new risk locus for the development of type 2 diabetes.
rs10965250
rs11165354
rs11634397
rs11642841
rs11708067Risk alleles near ADCY5 increase plasma glucose levels at birth and in early childhood.
rs11868035Causes increased plasma free fatty acids, predisposing to early cognitive impairment in type 2 diabetes mellitus.
rs12255372Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with a significant increase in the risk of type 2 diabetes.
rs12304921
rs12970134A common obesity variant near the MC4R gene is associated with higher intake of total energy and dietary fat, weight change, insulin resistance and risk of type 2 diabetes.
rs13266634The zinc transporter gene SLC30A8 polymorphism is associated with type 2 diabetes.
rs16861329
rs17036101
rs17053082
rs17584499
rs17797882
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