Normal allele: TT
The common variant rs9939609 of the FTO gene, associated with fat mass and obesity, is associated with fat cell lipolysis as well as early onset of extreme obesity. Studies show that carriers of the risk allele A demonstrate significantly greater weight loss on a fat-restricted diet than non-carriers.
Polymorphism rs9939609 is related to topics like this:
Type 2 diabetes is the most prevalent and impactful subtype of diabetes worldwide, affecting around...
Approximately 15% of couples of reproductive age are affected by infertility, which is a complex...
Although physical inactivity and consuming energy-dense foods are commonly identified as the main...
Dieters can determine which diet would result in more weight loss by undergoing a genetic test,...
The healthy eating habits of individuals residing in countries surrounding the Mediterranean Sea,...
The American Heart Association (AHA) suggests a low-fat diet as a healthy eating practice, which...
Research and publications :
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
FTO polymorphisms in oceanic populations
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs
Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment
Association of the FTO gene with BMI
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes
The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks
Regulation of Fto/Ftm gene expression in mice and humans
NYD-SP18 is associated with obesity in the NHLBI Family Heart Study
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
Variations in the FTO gene are associated with severe obesity in the Japanese
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity
Common variants near MC4R are associated with fat mass, weight and risk of obesity
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome
Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population
Worldwide population differentiation at disease-associated SNPs
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study
Obesity associated genetic variation in FTO is associated with diminished satiety
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
FTO variants are associated with obesity in the Chinese and Malay populations in Singapore
Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain
Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test
Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness
The FTO gene is associated with adulthood obesity in the Mexican population
FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
Fat mass and obesity related gene (FTO): no significant association of the rs9939609 variant with lifestyle weight loss and lipid markers in obese German children and adolescents.
The FTO gene and measured food intake in children
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program
The fat mass- and obesity-associated locus and dietary intake in children
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
The search for putative unifying genetic factors for components of the metabolic syndrome
The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients
Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels
Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609
FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians
Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
How does body fat influence bone mass in childhood? A Mendelian randomization approach
Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
An obesity-associated FTO gene variant and increased energy intake in children
ATOM: a powerful gene-based association test by combining optimally weighted markers
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity
An open access database of genome-wide association results
The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men
Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss
Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention
Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes
Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants
FTO gene variation and measures of body mass in an African population
Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy
Validating, augmenting and refining genome-wide association signals
Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults
Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study
No association of multiple type 2 diabetes loci with type 1 diabetes
Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
Genetic variation of FTO and TCF7L2 in premature adrenarche
Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
Common body mass index-associated variants confer risk of extreme obesity
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue
The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes
Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study
Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
Recommendations for using standardised phenotypes in genetic association studies
Pediatric obesity: etiology and treatment
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases
Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO
Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study
Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
The FTO gene rs9939609 obesity-risk allele and loss of control over eating
Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women
Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study
A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity
Life course variations in the associations between FTO and MC4R gene variants and body size
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
