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SNP information rs2237897

RS2237897

Normal allele: CC

A common variant in the KCNQ1 gene cause an increased risk of developing type 2 diabetes and contribute to the diabetes epidemic.

Polymorphism rs2237897 is related to topics like this:

Type 2 diabetes genetic

Type 2 diabetes is the most prevalent and impactful subtype of diabetes worldwide, affecting around...


Research and publications:

  18711366   SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.

  19252135   Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.

  19308350   Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population.

  19366866   Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.

  19448982   Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China.

  19516902   The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.

  19556355   Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

  19575309   Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population.

  20056949   A single nucleotide polymorphism in KCNQ1 is associated with susceptibility to diabetic nephropathy in japanese subjects with type 2 diabetes.

  20174558   A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.

  20701788   KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.

  20865176   Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups.

  21261977   Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.

  21289621   Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.

  21357383   No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.

  21602532   Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.

  21750171   No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE.

  21767287   Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.

  21890495   Multi-ethnic studies in complex traits.

  22125221   Transethnic meta-analysis of genomewide association studies.

  22403629   Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp.

  22479571   Several polymorphisms of KCNQ1 gene are associated with plasma lipid levels in general Chinese populations.

  22623978   A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.

  22696034   KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes.

  23271129   Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes.

  23298195   Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.

  23544998   Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.

  23786590   Common variants in KCNQ1 confer increased risk of type 2 diabetes and contribute to the diabetic epidemic in East Asians: a replication and meta-analysis.

  25145545   Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?

  25516658   Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan.

  25587982   Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.

  25749274   Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among Chinese Han population.

  26066992   Genetic variants of potassium voltage-gated channel genes (KCNQ1, KCNH2, and KCNE1) affected the risk of atrial fibrillation in elderly patients.

  26290879   Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China.

  26678516   Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population.

  26818947   Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

  26911676   Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.

  26927145   Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China.

  27042264   Genetics of cardiovascular and renal complications in diabetes.

  27175665   Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals.

  30515958   Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine.

  31123324   ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes.

  31231424   Genetic and Epigenetic Studies in Diabetic Kidney Disease.

  31324086   SNP in KCNQ1 Gene is Associated with Susceptibility to Diabetic Nephropathy in Subjects with Type 2 Diabetes in India.

  32695830   Associations of KCNQ1 Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An Updated Meta-Analysis with Trial Sequential Analysis.

  32922204   Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population.

  33752320   Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus.

  34502231   Common Genetic Aberrations Associated with Metabolic Interferences in Human Type-2 Diabetes and Acute Myeloid Leukemia: A Bioinformatics Approach.

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