SNP information rs4430796

Research and publications:

  18491292   Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.

  18591388   Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

  18694974   Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

  18701471   Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.

  18758462   Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.

  18794092   Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.

  19058137   Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.

  19096518   A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.

  19104501   Prostate cancer genomics: towards a new understanding.

  19116992   Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancer.

  19117981   Sequence variants at 22q13 are associated with prostate cancer risk.

  19168595   Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.

  19188186   Genetic variants and family history predict prostate cancer similar to prostate-specific antigen.

  19318432   Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.

  19324937   Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults

  19341491   Genome-based prediction of common diseases: methodological considerations for future research

  19366828   Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.

  19366831   Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.

  19371897   Pathological outcomes associated with the 17q prostate cancer risk variants.

  19434657   Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19526209   Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

  19549807   Prostate cancer risk associated loci in African Americans.

  19627283   Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness?

  19726753   Replication of prostate cancer risk loci in a Japanese case-control association study.

  19727433   Cancer genetic association studies in the genome-wide age.

  19767754   Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.

  19794065   Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes

  19862325   PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population

  19866473   Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men.

  19998368   HNF1B and JAZF1 genes, diabetes, and prostate cancer risk.

  20026053   WITHDRAWN: Relationships between 8q24 and 17q risk loci and sporadic or latent prostate cancer and the impacts of these loci on the clinicopathologic characteristics of prostate cancer.

  20039378   Estimation of genotype relative risks from pedigree data by retrospective likelihoods.

  20043145   Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

  20043853   Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

  20075150   Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

  20161779   Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

  20203524   Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk

  20450899   Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.

  20460480   Susceptibility loci associated with prostate cancer progression and mortality.

  20505153   A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

  20509872   Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

  20564319   Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.

  20569440   Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.

  20585100   Genome-wide association studies of cancer.

  20590552   The number of prostate cancer risk alleles may reveal a possibly “minor” disease.

  20620408   Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk.

  20651075   Prostate cancer susceptibility variants confer increased risk of disease progression.

  20667146   Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?

  20690139   Meta-analysis of genome-wide and replication association studies on prostate cancer.

  20816152   Obesity and diabetes genetic variants associated with gestational weight gain.

  20826827   Context-dependent effects of genome-wide association study genotypes and macroenvironment on time to biochemical (prostate specific antigen) failure after prostatectomy.

  20860009   Prostate cancer risk alleles significantly improve disease detection and are associated with aggressive features in patients with a "normal" prostate specific antigen and digital rectal examination.

  20862305   Identification of new genetic risk variants for type 2 diabetes.

  20865176   Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups.

  20870969   Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study

  20878950   Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.

  20886378   Physiologic characterization of type 2 diabetes-related loci

  21071540   Validation of genome-wide prostate cancer associations in men of African descent.

  21135144   Inherited variants in the chemokine CCL2 gene and prostate cancer aggressiveness in a Caucasian cohort.

  21160077   Genetic correction of PSA values using sequence variants associated with PSA levels.

  21191145   Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.

  21209154   Efficient p-value evaluation for resampling-based tests.

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21295399   Polygenic risk score improves prostate cancer risk prediction: results from the Stockholm-1 cohort study.

  21343373   Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence.

  21367958   Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.

  21372204   Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study.

  21390317   Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.

  21456070   GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).

  21468051   Polygenic susceptibility to prostate and breast cancer: implications for personalised screening.

  21499250   Genome-wide association study identifies a common variant associated with risk of endometrial cancer.

  21538423   Early onset prostate cancer has a significant genetic component.

  21541972   Functional annotation of risk loci identified through genome-wide association studies for prostate cancer.

  21557267   A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population.

  21576123   Large-scale fine mapping of the HNF1B locus and prostate cancer risk.

  21756274   Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men.

  21769933   A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.

  21820706   Prostate cancer risk alleles and their associations with other malignancies.

  21829199   Genetic architecture of prostate cancer in the Ashkenazi Jewish population.

  21856995   Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk.

  21959049   Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population.

  22077888   Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.

  22086326   Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions.

  22101116   Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened men.

  22125221   Transethnic meta-analysis of genomewide association studies.

  22144497   Assessing the clinical role of genetic markers of early-onset prostate cancer among high-risk men enrolled in prostate cancer early detection.

  22181854   Prostate cancer genomics, biology, and risk assessment through genome-wide association studies.

  22198737   Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG).

  22219177   A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.

  22237986   Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.

  22350825   Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.

  22459122   Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to prostate cancer risk in the National Cancer Institute Breast and Pros

  22561070   8q24 and 17q prostate cancer susceptibility loci in a multiethnic Asian cohort.

  22730461   Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis.

  22985493   Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis.

  23185337   Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.

  23193118   Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium

  23246478   Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies.