SNP information rs12970134

Research and publications:

  18454146   Common genetic variation near MC4R is associated with waist circumference and insulin resistance.

  18697794   The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.

  19073769   Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes

  19265794   Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.

  19478790   The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

  19680233   Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs.

  19822564   Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types

  19889825   Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.

  20092643   Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

  20110568   Combined analyses of 20 common obesity susceptibility variants.

  20127379   From monogenic to polygenic obesity: recent advances.

  20181787   A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake.

  20397748   Genome-wide association study of height and body mass index in Australian twin families.

  20694148   A genome-wide association study of the metabolic syndrome in Indian Asian men.

  20712903   Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study

  20816195   Analyses of shared genetic factors between asthma and obesity in children.

  20966902   Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

  21085626   Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.

  21150882   Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.

  21152014   Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.

  21283731   FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

  21372613   Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention.

  21466928   Genetics and epigenetics of obesity.

  21544599   Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth.

  21573225   Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine.

  21625854   Implication of genetic variants near TMEM18, BCDIN3D/FAIM2, and MC4R with coronary artery disease and obesity in Chinese: a angiography-based study.

  21736789   A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population.

  21785715   Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.

  21799482   Common genetic variants and central adiposity among Asian-Indians.

  21848424   Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.

  21976109   Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study.

  22355368   Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood.

  22614171   Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

  22869321   Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.

  23049848   Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.

  23173044   Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.

  23339409   Reduced genetic influence on childhood obesity in small for gestational age children.

  23512951   Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program.

  23712987   Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study.

  24458218   Association of INSIG2 rs9308762 with ALT level independent of BMI.

  24675148   The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy.

  24820477   Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

  24843659   Insights into the genetic basis of type 2 diabetes.

  24845081   Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

  24864266   Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.

  25093408   Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population.

  25239271   Fine mapping of type 2 diabetes susceptibility loci.

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  25948074   Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort.

  26363598   Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits.

  26964836   Recent progress in genetic and epigenetic research on type 2 diabetes.

  27053236   Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.

  27186233   The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome.

  27312935   Genetics of Insulin Resistance and the Metabolic Syndrome.

  27314342   A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence.

  28081251   Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents.

  28520814   Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population.

  28821857   CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.

  29325775   Nutrigenetic variants and cardio-metabolic risk in women with or without gestational diabetes.

  30584432   Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

  30896429   Combined effect of FTO and MC4R gene polymorphisms on obesity in children and adolescents in Northwest China: a case-control study.

  30945034   The MC4R genetic variants are associated with lower visceral fat accumulation and higher postprandial relative increase in carbohydrate utilization in humans.

  31429705   MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.

  31781208   MC4R Single Nucleotide Polymorphisms Were Associated with Metabolically Healthy and Unhealthy Obesity in Chinese Northern Han Populations.

  32228543   Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients.

  32390949   Genetic Susceptibility to Gestational Diabetes Mellitus in a Chinese Population.

  32446744   The interaction between dietary patterns and melanocortin-4 receptor polymorphisms in relation to obesity phenotypes.

  32740722   Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population.

  32770936   The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity.

  32899047   Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  33468396   Insulin resistance-associated genetic variants in type 1 diabetes.

  33552632   Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents.

  33605492   Heterogeneous long-term trajectories of glycaemic control in type 1 diabetes.

  33668547   Effects of Gene-Environment Interaction on Obesity among Chinese Adults Born in the Early 1960s.

  34628278   Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: A systematic review.

  34769477   An Association between Diet and MC4R Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters-A Cross Sectional Population-Based Study.

  35456451   Gene-Environment Interaction on Type 2 Diabetes Risk among Chinese Adults Born in Early 1960s.

  35495128   MC4R Gene Polymorphisms Interact With the Urbanized Living Environment on Obesity: Results From the Yi Migrant Study.