HHEX gene polymorphism is associated with impaired proinsulin conversion and increased risk of developing type 2 diabetes.
Research and publications:
17786204 Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
17786212 Heterogeneity in meta-analyses of genome-wide association investigations
17827400 Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
17928989 Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
17971426 Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.
18039816 A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.
18162508 Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
18224312 Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment
18231124 HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.
18264689 Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
18423522 Estimating odds ratios in genome scans: an approximate conditional likelihood approach
18426861 Association analysis of type 2 diabetes Loci in type 1 diabetes
18437351 Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
18443202 Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
18461161 Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
18469204 Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
18477659 Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.
18533027 Worldwide population differentiation at disease-associated SNPs
18544707 Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
18556337 Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
18591388 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
18633108 Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
18689899 Exchangeable models of complex inherited diseases
18694974 Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
18782870 Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008
18852197 Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
18991055 Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
19001172 Analysis of the National Institute on Aging Family Study of Late-Onset Alzheimer's Disease: Impact of Additional Loci.
19002430 Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population
19008344 Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
19020323 Genotype score in addition to common risk factors for prediction of type 2 diabetes
19033397 Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
19056611 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
19096518 A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.
19117022 The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort.
19161620 An open access database of genome-wide association results
19228808 Type 2 diabetes risk alleles are associated with reduced size at birth.
19258437 Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.
19279076 Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
19324937 Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults
19341491 Genome-based prediction of common diseases: methodological considerations for future research
19401414 Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
19455305 No association of multiple type 2 diabetes loci with type 1 diabetes
19460916 Genetic architecture of type 2 diabetes: recent progress and clinical implications
19502414 Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
19592620 Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.
19615048 Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies.
19626703 Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies
19741467 Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
19794065 Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
19808892 Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
19862325 PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
19933996 Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.
19956539 How many genetic variants remain to be discovered?
20017978 Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study
20018041 The effect of multiple genetic variants in predicting the risk of type 2 diabetes
20041287 Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome.
20043853 Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
20049090 Association between type 2 diabetes loci and measures of fatness
20075150 Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
20080751 Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
20126254 Rare variants create synthetic genome-wide associations.
20142250 Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study
20144318 A strategy for analyzing gene-nutrient interactions in type 2 diabetes.
20144327 A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel
20161779 Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
20203524 Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk
20424228 Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.
20490451 Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
20532014 The epidemiology of diabetes in Korea: from the economics to genetics.
20550665 Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
20647405 No association between FTO or HHEX and endometrial cancer risk.
20712903 Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study
20865176 Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups.
20870969 Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study
20886378 Physiologic characterization of type 2 diabetes-related loci
20929593 The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI.
20979565 Population structure of Aggarwals of north India as revealed by molecular markers.
20980412 Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study
21056935 Quantitative assessment of the influence of hematopoietically expressed homeobox variant (rs1111875) on type 2 diabetes risk.
21059810 Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes.
21084393 Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.
21091714 The genetics of type 2 diabetes: what have we learned from GWAS?
21103332 Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies
21124985 Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
21150882 Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.
21191145 Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.
21278902 Genetic risk profiling for prediction of type 2 diabetes
21283728 Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
21297524 The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.
21357383 No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.
21378175 Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program
21407270 Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.
21421807 Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
21424820 Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.
21444075 Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.
21490949 Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
21510814 Association of genetic variations in TCF7L2, SLC30A8, HHEX, LOC387761, and EXT2 with Type 2 diabetes mellitus in Tunisia.
21533175 Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
21565292 Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies.
