Locus of risk for developing type 2 diabetes as well as increased risk for gestational diabetes.
Research and publications:
17463246 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
17463248 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
17463249 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
17786212 Heterogeneity in meta-analyses of genome-wide association investigations
17827400 Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
18162508 Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
18224312 Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment
18264689 Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
18319073 Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes
18423522 Estimating odds ratios in genome scans: an approximate conditional likelihood approach
18426861 Association analysis of type 2 diabetes Loci in type 1 diabetes
18430866 Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians.
18437351 Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
18443202 Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
18461161 Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
18469204 Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
18477659 Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.
18533027 Worldwide population differentiation at disease-associated SNPs
18544707 Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
18591388 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
18633108 Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
18689899 Exchangeable models of complex inherited diseases
18694974 Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
18782870 Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008
18852197 Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
18853134 The search for putative unifying genetic factors for components of the metabolic syndrome
18991055 Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
19002430 Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population
19008344 Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
19033397 Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
19056611 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
19096518 A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.
19148120 Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans.
19207020 Meta-analysis in genome-wide association studies
19228808 Type 2 diabetes risk alleles are associated with reduced size at birth.
19258437 Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.
19279076 Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
19323962 Genome-wide association studies in type 2 diabetes
19324937 Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults
19341491 Genome-based prediction of common diseases: methodological considerations for future research
19401414 Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
19455305 No association of multiple type 2 diabetes loci with type 1 diabetes
19460916 Genetic architecture of type 2 diabetes: recent progress and clinical implications
19502414 Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
19526209 Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
19592620 Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.
19602701 Underlying genetic models of inheritance in established type 2 diabetes associations
19626703 Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies
19734549 Ranking of genome-wide association scan signals by different measures
19741467 Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
19794065 Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
19808892 Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
19902174 Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome.
19931040 Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies
19933996 Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.
19956539 How many genetic variants remain to be discovered?
20017978 Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study
20018066 Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
20043145 Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
20049090 Association between type 2 diabetes loci and measures of fatness
20126254 Rare variants create synthetic genome-wide associations.
20142250 Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study
20144327 A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel
20161779 Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
20203524 Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk
20215779 Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes.
20362271 Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.
20384434 Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism.
20424228 Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.
20509872 Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
20532014 The epidemiology of diabetes in Korea: from the economics to genetics.
20550665 Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
20627640 IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes.
20712903 Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study
20802253 Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
20805105 Synthetic associations in the context of genome-wide association scan signals
20816152 Obesity and diabetes genetic variants associated with gestational weight gain.
20862305 Identification of new genetic risk variants for type 2 diabetes.
20865176 Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups.
20870969 Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study
20886378 Physiologic characterization of type 2 diabetes-related loci
20929593 The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI.
20980412 Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study
21058334 MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes.
21091714 The genetics of type 2 diabetes: what have we learned from GWAS?
21103332 Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies
21124985 Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
21133856 Genome-wide association scan allowing for epistasis in type 2 diabetes.
21191145 Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.
21217814 Presymptomatic risk assessment for chronic non-communicable diseases.
21278902 Genetic risk profiling for prediction of type 2 diabetes
21283728 Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
21297524 The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.
21357383 No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.
21368910 Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.
21421807 Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
21444075 Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.
21467728 Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
21565292 Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies.
21573907 Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
