SNP information rs7903146

Research and publications:

  16415884   Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

  16855264   TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

  16936215   Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk

  16936217   Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample

  16936218   Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance

  17003358   Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

  17003360   Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes

  17020404   Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

  17031610   Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

  17065361   TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

  17093941   Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population

  17130514   Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women

  17181866   Effects of the diabetes linked TCF7L2 polymorphism in a representative older population

  17206141   Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

  17226113   Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys

  17245407   TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

  17245589   A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

  17259383   Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans

  17311858   TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children

  17340123   Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

  17342473   A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus

  17416797   TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

  17429603   TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

  17437080   Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

  17460697   A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

  17463246   Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

  17463248   A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

  17463249   Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

  17470138   Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City

  17476472   TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

  17503332   Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals

  17519421   Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

  17579206   Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population

  17593304   TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

  17601994   Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy

  17609304   Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese

  17618413   Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men

  17661009   Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

  17668382   Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

  17671651   Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

  17683561   The TCF7L2 locus and type 1 diabetes

  17697858   The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians

  17725629   The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  17805508   Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS

  17903298   Genome-wide association with diabetes-related traits in the Framingham Heart Study

  17934151   A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

  17971425   Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

  17972059   TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia

  17977958   Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study

  18097733   Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18239663   Effects of TCF7L2 polymorphisms on obesity in European populations

  18248681   Prevalence of common disease-associated variants in Asian Indians

  18264689   Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

  18268068   Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study

  18282109   Adaptations to climate in candidate genes for common metabolic disorders

  18282631   Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects

  18291022   Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population

  18310307   Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes

  18319073   Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes

  18335027   Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP

  18372903   Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

  18397358   TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels

  18398040   Transcription factor 7-like 2 polymorphism and colon cancer

  18423522   Estimating odds ratios in genome scans: an approximate conditional likelihood approach

  18437354   TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study

  18443202   Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies

  18461161   Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

  18469204   Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

  18481957   TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

  18493736   Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population

  18498634   The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

  18498660   Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study

  18546086   TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children

  18555673   The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects

  18556337   Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)

  18591388   Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

  18598350   Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk

  18611970   Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins

  18650481   TCF7L2 variants associate with CKD progression and renal function in population-based cohorts

  18654633   Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies

  18654799   Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease

  18655717   Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

  18678618   Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes

  18689695   Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

  18689899   Exchangeable models of complex inherited diseases

  18694974   Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

  18706099   TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes

  18712344   Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population

  18762805   Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyle intervention

  18782870   Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008

  18839133   Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients

  18852197   Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

  18853134   The search for putative unifying genetic factors for components of the metabolic syndrome

  18931037   Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study

  18958766   Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome

  18972257   Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study

  18992263   Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways

  18996470   Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes