SNP information rs7756992

Research and publications:

  17460697   A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  17928989   Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.

  18162508   Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population

  18210030   Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.

  18426861   Association analysis of type 2 diabetes Loci in type 1 diabetes

  18437351   Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)

  18461161   Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

  18469204   Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

  18477659   Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.

  18633108   Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

  18835935   Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).

  19002430   Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

  19008344   Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians

  19033397   Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

  19279076   Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men

  19401414   Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population

  19455305   No association of multiple type 2 diabetes loci with type 1 diabetes

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19592620   Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

  19718565   Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 are not associated with polycystic ovary syndrome in Chinese women.

  19741166   Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19862325   PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population

  19933996   Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.

  20043145   Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

  20080751   Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

  20203524   Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk

  20490451   Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

  20580033   Replication of recently described type 2 diabetes gene variants in a South Indian population.

  21103332   Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21297524   The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.

  21368910   Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

  21416855   [Relationship of the CDKAL1 and KCNQ1 gene polymorphisms to the age at diagnosis of type 2 diabetes in the Slovakian population].

  21444075   Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

  21611789   The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.

  22052079   Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.

  22119613   Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.

  22233651   A genome-wide association study of gestational diabetes mellitus in Korean women

  22292718   Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas.

  22333905   Estimating the contribution of genetic variants to difference in incidence of disease between population groups.

  22708638   Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial

  22923468   Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.

  23185337   Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.

  23185617   Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants

  23349771   Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs.

  24012816   The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: a meta-analysis.

  24185407   CDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects.

  24636221   Contribution of CDKAL1 rs7756992 and IGF2BP2 rs4402960 polymorphisms in type 2 diabetes, diabetic complications, obesity risk and hypertension in the Tunisian population.

  24637646   Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese

  24653947   Cumulative Effect of Common Genetic Variants Predicts Incident Type 2 Diabetes: A Study of 21,183 Subjects from Three Large Prospective Cohorts.

  24760768   Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human.

  24845081   Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

  24898818   Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.

  24906951   Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes.

  24935819   Exploring genetic variants predisposing to diabetes mellitus and their association with indicators of socioeconomic status.

  25145545   Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?

  25288178   The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk in Chinese: a meta-analysis.

  25587982   Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.

  25634229   A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1.

  25658847   Do variants associated with susceptibility to pancreatic cancer and type 2 diabetes reciprocally affect risk?

  25723968   Identification of Genetic Variants of Gestational Diabetes in South Indians.

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  26042206   Gene-gene and gene-environment interactions in the etiology of type 2 diabetes mellitus in the population of Hyderabad, India.

  26168825   Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.

  26240488   Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.

  26648684   Update on genetics and diabetic retinopathy.

  26806836   Genetic and clinical variables identify predictors for chronic kidney disease in type 2 diabetes.

  26873362   Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population.

  26961502   Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

  26983698   Joint effects of diabetic-related genomic loci on the therapeutic efficacy of oral anti-diabetic drugs in Chinese type 2 diabetes patients.

  27139004   A Common Susceptibility Gene for Type 2 Diabetes Is Associated with Drug Response to a DPP-4 Inhibitor: Pharmacogenomic Cohort in Okinawa Japan.

  27275426   The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population.

  27281091   Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population: A case-control study.

  27294943   Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis.

  27377502   Association of CDKAL1, CDKN2A/B & HHEX gene polymorphisms with type 2 diabetes mellitus in the population of Hyderabad, India.

  27383215   Type 2 Diabetes Risk Allele Loci in the Qatari Population.

  27424552   Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.

  27588103   IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study.

  27589775   Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese.

  28717589   Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population.

  28738793   Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

  28821857   CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.

  29372795   [The analysis of association between type 2 diabetes and polymorphic markers in the CDKAL1 gene and in the HHEX/IDE locus].

  29871606   Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population.

  30074174   Meta-analysis of GABRB3 Gene Polymorphisms and Susceptibility to Autism Spectrum Disorder.

  30647622   Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians.

  32722593   Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies.

  32764395   Dietary Protein and Fat Intake Affects Diabetes Risk with CDKAL1 Genetic Variants in Korean Adults.

  33965365   The risk variant of CDKAL1 (rs7756992) impairs fasting glucose levels and insulin resistance improvements after a partial meal-replacement hypocaloric diet.

  34131278   Genetic polymorphisms associated with obesity in the Arab world: a systematic review.

  34178825   Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population.

  34665019   Pharmacogenetics of sulfonylurea-induced hypoglycemia in Type 2 diabetes patients: the SUCLINGEN study.

  34721291   CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Gene Polymorphisms and Gestational Diabetes Mellitus Risk: A Trial Sequential Meta-Analysis of 13,306 Subjects.

  34803393   Pharmacogenomics and Personalized Medicine in Type 2 Diabetes Mellitus: Potential Implications for Clinical Practice.

  35090536   CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis.