SNP information rs7754840

Research and publications:

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18264689   Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

  18285412   Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

  18423522   Estimating odds ratios in genome scans: an approximate conditional likelihood approach

  18426861   Association analysis of type 2 diabetes Loci in type 1 diabetes

  18443202   Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies

  18461161   Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

  18469204   Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

  18477659   Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.

  18516622   Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population.

  18544707   Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

  18598350   Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk

  18633108   Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

  18689899   Exchangeable models of complex inherited diseases

  18694974   Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

  18714373   Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.

  18782870   Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008

  18985156   Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

  18991055   Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.

  19002430   Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

  19008344   Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians

  19020323   Genotype score in addition to common risk factors for prediction of type 2 diabetes

  19033397   Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

  19088850   Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

  19172244   The risk allele load accelerates the age-dependent decline in beta cell function.

  19258437   Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.

  19324937   Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults

  19341491   Genome-based prediction of common diseases: methodological considerations for future research

  19366866   Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.

  19401414   Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population

  19460916   Genetic architecture of type 2 diabetes: recent progress and clinical implications

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19502414   Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men

  19592620   Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

  19615048   Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies.

  19626703   Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies

  19789630   Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.

  19794065   Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes

  19808892   Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

  19862325   PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population

  19956539   How many genetic variants remain to be discovered?

  20017978   Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study

  20043853   Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

  20049090   Association between type 2 diabetes loci and measures of fatness

  20080751   Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

  20126254   Rare variants create synthetic genome-wide associations.

  20142250   Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study

  20144327   A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel

  20532014   The epidemiology of diabetes in Korea: from the economics to genetics.

  20580033   Replication of recently described type 2 diabetes gene variants in a South Indian population.

  20712903   Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study

  20802253   Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

  20847104   Invited commentary: Gene X lifestyle interactions and complex disease traits--inferring cause and effect from observational data, sine qua non.

  20865176   Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups.

  20870969   Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study

  20886378   Physiologic characterization of type 2 diabetes-related loci

  20980412   Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study

  21084393   Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.

  21091714   The genetics of type 2 diabetes: what have we learned from GWAS?

  21152029   Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function

  21191145   Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21283728   Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.

  21357383   No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.

  21378175   Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program

  21407270   Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.

  21421807   Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

  21424820   Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.

  21444075   Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21490949   Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.

  21565292   Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies.

  21602532   Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.

  21611789   The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.

  21643948   Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals.

  21750171   No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE.

  21890495   Multi-ethnic studies in complex traits.

  21911746   Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study.

  21957892   Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome.

  22038522   Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism

  22052079   Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.

  22096510   Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population

  22119613   Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.

  22125221   Transethnic meta-analysis of genomewide association studies.

  22233651   A genome-wide association study of gestational diabetes mellitus in Korean women

  22307069   Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial

  22350825   Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.

  22923468   Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.

  23029294   Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus

  23173044   Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.

  23193118   Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium

  23458876   ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.

  23462794   Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

  23690305   Genetic variants and the risk of gestational diabetes mellitus: a systematic review

  24012816   The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: a meta-analysis.

  24062323   Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes.

  24112421   CDKAL1 and HHEX are associated with traits of type 2 diabetes in Yupik people.

  24719615   Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.

  24906951   Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes.