SNP information rs4506565

Research and publications:

  16936215   Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk

  17093941   Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population

  17934151   A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18655717   Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

  19053027   Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

  19161620   An open access database of genome-wide association results

  19252133   Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.

  19351735   Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.

  19913122   ATRIUM: testing untyped SNPs in case-control association studies with related individuals.

  19931040   Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies

  20018066   Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study

  20039379   A powerful approach to sub-phenotype analysis in population-based genetic association studies.

  20081858   New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20693352   Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

  20876667   Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

  20979565   Population structure of Aggarwals of north India as revealed by molecular markers.

  20980453   Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.

  21036813   A variable selection method for genome-wide association studies.

  21103350   Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese

  21188353   Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans

  21217814   Presymptomatic risk assessment for chronic non-communicable diseases.

  21251252   An empirical evaluation of imputation accuracy for association statistics reveals increased type-I error rates in genome-wide associations.

  21368910   Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

  21810599   Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis

  21949744   Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes

  21975967   Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes care

  22238593   A genome-wide association search for type 2 diabetes genes in African Americans.

  22301903   Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS.

  22583123   Association of TCF7L2 and ADIPOQ with body mass index, waist-hip ratio, and systolic blood pressure in an endogamous ethnic group of India.

  22971100   Quick, "imputation-free" meta-analysis with proxy-SNPs.

  23107111   Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.

  23142382   Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.

  23188737   TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects.

  23281810   Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.

  23626757   Development of GMDR-GPU for gene-gene interaction analysis and its application to WTCCC GWAS data for type 2 diabetes.

  24128935   Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.

  24157263   Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).

  24959828   Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population.

  25393876   Identification of allelic heterogeneity at type-2 diabetes loci and impact on prediction.

  25477898   Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  26367734   Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.

  26866580   The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research.

  27049325   Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.

  27058589   Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis.

  27153677   Assessing statistical significance in multivariable genome wide association analysis.

  27185397   Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases.

  27296613   Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans.

  27310578   Replication and Relevance of Multiple Susceptibility Loci Discovered from Genome Wide Association Studies for Type 2 Diabetes in an Indian Population.

  27383215   Type 2 Diabetes Risk Allele Loci in the Qatari Population.

  27695091   CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates.

  27790247   Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

  27892471   Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies.

  28738793   Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

  29025879   TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.

  29947923   Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations.

  31288068   A meta-analysis on genetic associations between Transcription Factor 7 Like 2 polymorphisms and type 2 diabetes mellitus.

  32445548   Association between type 2 diabetes mellitus & TCF7L2 gene variants in the Emirati population: Genetics of diabetes in the United Arab Emirates.

  32948839   GWA-based pleiotropic analysis identified potential SNPs and genes related to type 2 diabetes and obesity.

  33017871   Impact of type 2 diabetes variants identified through genome-wide association studies in early-onset type 2 diabetes from South Indian population.

  35601672   Diabetes, cigarette smoking and transcription factor 7-like 2 (Tcf7L2) in the UK Biobank cohort.

  35664972   Metabolic syndrome-related SNPs in HLA and TNF7L2 may be risk factors for generalized pustular psoriasis in Chinese Han population.

  35966063   The correlation between transcription factor 7-like 2 gene polymorphisms and susceptibility of gestational diabetes mellitus in the population of central China: A case-control study.