The zinc transporter gene SLC30A8 polymorphism is associated with type 2 diabetes.
Research and publications:
17293876 A genome-wide association study identifies novel risk loci for type 2 diabetes.
17460697 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
17463246 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
17463248 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
17463249 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
17786204 Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
17786212 Heterogeneity in meta-analyses of genome-wide association investigations
17928989 Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
17971426 Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.
18162508 Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
18162509 A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.
18210030 Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.
18224312 Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment
18264689 Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
18324385 The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.
18400535 A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.
18426861 Association analysis of type 2 diabetes Loci in type 1 diabetes
18437351 Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
18443202 Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
18461161 Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
18469204 Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
18498634 The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
18533027 Worldwide population differentiation at disease-associated SNPs
18544707 Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
18548167 SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset.
18556337 Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
18591387 A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.
18591388 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
18598350 Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
18628523 Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese.
18633108 Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
18654633 Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies
18689899 Exchangeable models of complex inherited diseases
18694974 Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
18782870 Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008
18850084 Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.
18852197 Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
18991055 Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
19002430 Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population
19008344 Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
19020323 Genotype score in addition to common risk factors for prediction of type 2 diabetes
19033397 Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
19056611 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
19096518 A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.
19108828 Genetic variations of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) are not associated with polycystic ovary syndrome.
19161620 An open access database of genome-wide association results
19172244 The risk allele load accelerates the age-dependent decline in beta cell function.
19207020 Meta-analysis in genome-wide association studies
19228808 Type 2 diabetes risk alleles are associated with reduced size at birth.
19258437 Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.
19279076 Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
19324937 Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults
19341491 Genome-based prediction of common diseases: methodological considerations for future research
19401414 Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
19455305 No association of multiple type 2 diabetes loci with type 1 diabetes
19460916 Genetic architecture of type 2 diabetes: recent progress and clinical implications
19502414 Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
19526209 Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
19542200 Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.
19590848 Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk.
19592620 Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.
19602701 Underlying genetic models of inheritance in established type 2 diabetes associations
19626703 Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies
19651813 Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits
19655390 Zn(2+)-transporter-8: a dual role in diabetes.
19734549 Ranking of genome-wide association scan signals by different measures
19741166 Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study
19741467 Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
19794065 Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
19808892 Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
19862325 PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
19875614 A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
19933996 Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.
19956108 Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
19956539 How many genetic variants remain to be discovered?
20017978 Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study
20018041 The effect of multiple genetic variants in predicting the risk of type 2 diabetes
20043853 Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
20049090 Association between type 2 diabetes loci and measures of fatness
20075150 Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
20081858 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
20138556 Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets.
20142250 Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study
20144318 A strategy for analyzing gene-nutrient interactions in type 2 diabetes.
20144327 A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel
20161779 Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
20167458 SLC30A8 polymorphism and type 2 diabetes risk: evidence from 27 study groups.
20185807 Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans
20203524 Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk
20351753 A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion.
20424228 Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.
20509872 Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
20532014 The epidemiology of diabetes in Korea: from the economics to genetics.
20550665 Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
20554072 Gestational diabetes mellitus screening based on the gene chip technique.
20712903 Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study
20802253 Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
20805105 Synthetic associations in the context of genome-wide association scan signals
20805255 Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population
20809084 Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients.
