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SNP information rs5215


Normal allele: TT

A common genetic variant with moderate effect of predisposition to type 2 diabetes and obesity.

Polymorphism rs5215 is related to topics like this:

Type 2 diabetes genetic

Type 2 diabetes is the most prevalent and impactful subtype of diabetes worldwide, affecting around...

Research and publications:

  16733889   [Association analysis of 30 type 2 diabetes candidate genes in Chinese Han population].

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  18414213   ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007.

  18426861   Association analysis of type 2 diabetes Loci in type 1 diabetes

  18533027   Worldwide population differentiation at disease-associated SNPs

  18591388   Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

  19002430   Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

  19096518   A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.

  19526209   Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

  19931040   Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies

  20017978   Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study

  20018041   The effect of multiple genetic variants in predicting the risk of type 2 diabetes

  20018066   Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study

  20043145   Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

  20144327   A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel

  20203524   Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20550665   Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

  20682687   Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

  20802253   Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

  20816152   Obesity and diabetes genetic variants associated with gestational weight gain.

  20820957   The Genetics of Insulin Resistance: Where's Waldo?

  20839289   Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose

  20862305   Identification of new genetic risk variants for type 2 diabetes.

  21103332   Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies

  21124985   Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.

  21217814   Presymptomatic risk assessment for chronic non-communicable diseases.

  21368910   Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

  21444075   Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

  21573802   Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals.

  22038522   Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism

  22237986   Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.

  22289434   Sequencing genes in silico using single nucleotide polymorphisms.

  22350825   Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.

  22377712   Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

  22529894   Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.

  22551073   LDGIdb: a database of gene interactions inferred from long-range strong linkage disequilibrium between pairs of SNPs.

  22558147   Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.

  22569928   Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus.

  22971100   Quick, "imputation-free" meta-analysis with proxy-SNPs.

  23073174   From genotype to human β cell phenotype and beyond

  23185337   Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.

  23193118   Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium

  23236286   Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.

  24442125   CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients.

  24604100   High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients.

  24845081   Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

  25247988   Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study.

  25368101   Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.

  25477898   Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.

  25587982   Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.

  25658847   Do variants associated with susceptibility to pancreatic cancer and type 2 diabetes reciprocally affect risk?

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25755232   Habitual coffee intake, genetic polymorphisms, and type 2 diabetes.

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  26240488   Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.

  26740944   Uncovering the molecular pathogenesis of congenital hyperinsulinism by panel gene sequencing in 32 Chinese patients.

  26789123   A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation.

  26937418   Candidate gene analysis supports a role for polymorphisms at TCF7L2 as risk factors for type 2 diabetes in Sudan.

  26964836   Recent progress in genetic and epigenetic research on type 2 diabetes.

  26977395   Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.

  27035118   Whole-genome re-sequencing for the identification of high contribution susceptibility gene variants in patients with type 2 diabetes.

  27053236   Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.

  27211558   Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.

  27347941   Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes.

  27353450   The genetic regulatory signature of type 2 diabetes in human skeletal muscle.

  27383215   Type 2 Diabetes Risk Allele Loci in the Qatari Population.

  27424552   Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.

  27555891   Pharmacogenetic studies update in type 2 diabetes mellitus.


  27900359   Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs.

  28262806   Functional annotation of sixty-five type-2 diabetes risk SNPs and its application in risk prediction.

  28738793   Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

  29303622   Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers.

  30169531   KCNJ11 variants and their effect on the association between serum potassium and diabetes risk in the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts.

  30239167   Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus.

  30515958   Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine.

  32375679   Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion.

  32722593   Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies.

  32930968   Pharmacogenomic Studies of Current Antidiabetic Agents and Potential New Drug Targets for Precision Medicine of Diabetes.

  33611546   Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

  34824904   Genetic diversity of "highly important pharmacogenes" in two South Asian populations.

  35124268   Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.

  35456451   Gene-Environment Interaction on Type 2 Diabetes Risk among Chinese Adults Born in Early 1960s.

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