SNP information rs7901695

Research and publications:

  16936218   Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance

  17245407   TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

  17245589   A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

  17311858   TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children

  17340123   Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

  17601994   Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy

  17661009   Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

  17668382   Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  17934151   A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

  17971425   Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

  18268068   Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study

  18291022   Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population

  18437354   TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study

  18469204   Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

  18533027   Worldwide population differentiation at disease-associated SNPs

  18591388   Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

  18650481   TCF7L2 variants associate with CKD progression and renal function in population-based cohorts

  18655717   Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

  18712344   Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population

  18780302   Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

  19050058   Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

  19053027   Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

  19056611   Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data

  19096518   A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.

  19161620   An open access database of genome-wide association results

  19207020   Meta-analysis in genome-wide association studies

  19228405   Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.

  19323962   Genome-wide association studies in type 2 diabetes

  19463184   Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.

  19526209   Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

  19602701   Underlying genetic models of inheritance in established type 2 diabetes associations

  19734549   Ranking of genome-wide association scan signals by different measures

  19750184   Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

  19913122   ATRIUM: testing untyped SNPs in case-control association studies with related individuals.

  19924244   TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.

  19931040   Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies

  20017978   Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study

  20075150   Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

  20144327   A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20816152   Obesity and diabetes genetic variants associated with gestational weight gain.

  20862305   Identification of new genetic risk variants for type 2 diabetes.

  20876667   Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

  20886378   Physiologic characterization of type 2 diabetes-related loci

  20980453   Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.

  21036813   A variable selection method for genome-wide association studies.

  21103332   Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies

  21133856   Genome-wide association scan allowing for epistasis in type 2 diabetes.

  21159844   Variants and haplotypes of TCF7L2 are associated with β-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.

  21188353   Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21297524   The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.

  21368910   Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

  21411509   Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.

  21444075   Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

  21507254   Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.

  21541012   Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium.

  21658257   The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity.

  21672010   Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.

  21799836   A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.

  21898192   Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.

  21975967   Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes care

  22189546   Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis.

  22199026   Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes.

  22307069   Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial

  22350825   Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.

  22377712   Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

  22427875   CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes. the Verona newly diagnosed type 2 diabetes study (VNDS) 3.

  22480428   T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.

  22558147   Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.

  22584884   The effect of type 2 diabetes risk loci on insulin requirements in type 1 diabetes.

  22843023   TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.

  22888288   Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population.

  23073174   From genotype to human β cell phenotype and beyond

  23107111   Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.

  23188737   TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects.

  23386860   Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.

  23456907   Maternal genotype and gestational diabetes

  23462794   Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

  23577239   Genetics of obesity and type 2 diabetes in African Americans.

  23626757   Development of GMDR-GPU for gene-gene interaction analysis and its application to WTCCC GWAS data for type 2 diabetes.

  24653947   Cumulative Effect of Common Genetic Variants Predicts Incident Type 2 Diabetes: A Study of 21,183 Subjects from Three Large Prospective Cohorts.

  25023634   Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.

  25469308   Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.

  25477898   Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México.

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  26345943   Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population.

  26393635   Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China.

  26648684   Update on genetics and diabetic retinopathy.

  27053236   Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.

  27058589   Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis.

  27153677   Assessing statistical significance in multivariable genome wide association analysis.

  27296613   Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans.

  27383215   Type 2 Diabetes Risk Allele Loci in the Qatari Population.

  27695091   CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates.

  27730450   Candidate gene studies of diabetic retinopathy in human.

  27790247   Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

  28002648   Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta-analysis.

  28067832   Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms.