SNP information rs12255372

Research and publications:

  16415884   Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

  16855264   TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

  16936216   Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.

  16936217   Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample

  16936218   Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance

  17003360   Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes

  17031610   Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

  17093941   Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population

  17109766   Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study.

  17130514   Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women

  17226113   Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys

  17245407   TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

  17245589   A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

  17259383   Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans

  17317761   Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans.

  17340123   Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

  17429603   TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

  17437080   Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

  17470138   Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City

  17503332   Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals

  17519421   Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

  17579206   Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population

  17601994   Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy

  17618413   Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men

  17661009   Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

  17665514   Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.

  17668382   Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

  17671651   Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

  17697858   The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians

  17805508   Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS

  17903298   Genome-wide association with diabetes-related traits in the Framingham Heart Study

  17909099   TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals.

  17934151   A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

  17971425   Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

  17972059   TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia

  18097733   Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

  18248681   Prevalence of common disease-associated variants in Asian Indians

  18268068   Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study

  18282631   Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects

  18291022   Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population

  18302196   Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study.

  18437354   TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study

  18478343   Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.

  18493736   Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population

  18598350   Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk

  18650481   TCF7L2 variants associate with CKD progression and renal function in population-based cohorts

  18655717   Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

  18706099   TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes

  18712344   Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population

  18972257   Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study

  19002430   Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

  19033397   Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

  19050058   Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

  19053027   Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

  19141698   Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia.

  19183934   TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.

  19211816   TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women.

  19228405   Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.

  19279076   Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men

  19309528   Specific and complete human genome amplification with improved yield achieved by phi29 DNA polymerase and a novel primer at elevated temperature.

  19351735   Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.

  19369405   Linkage analysis of albuminuria.

  19455305   No association of multiple type 2 diabetes loci with type 1 diabetes

  19482368   Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.

  19497595   Genetic variation of FTO and TCF7L2 in premature adrenarche

  19602480   Tissue-specific alternative splicing of TCF7L2.

  19732438   No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.

  19789636   Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.

  19825152   TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.

  19915463   Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes.

  19924244   TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.

  19934000   TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

  19996744   Fatty acid interactions with genetic polymorphisms for cardiovascular disease.

  20028944   Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes.

  20075150   Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

  20144327   A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel

  20161033   Personalized pharmacotherapy for Type 2 diabetes mellitus.

  20222815   Sulfonylurea pharmacogenomics in Type 2 diabetes: the influence of drug target and diabetes risk polymorphisms.

  20361036   Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20424228   Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.

  20503258   Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City.

  20648057   Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.

  20693352   Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

  20876667   Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

  20936101   Pharmacogenetics of Anti-Diabetes Drugs.

  21103332   Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies

  21109996   Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.

  21150882   Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.

  21159844   Variants and haplotypes of TCF7L2 are associated with β-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21286314   Genetics talks to epigenetics? The interplay between sequence variants and chromatin structure.

  21301999   Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters.

  21349175   TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.

  21368910   Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

  21399856   Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians.

  21423583   Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.

  21441683   Screening with OGTT alone or in combination with the Indian diabetes risk score or genotyping of TCF7L2 to detect undiagnosed type 2 diabetes in Asian Indians.

  21490949   Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.