SNP information rs10946398

Research and publications:

  17463246   Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

  17463248   A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

  17463249   Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

  17786212   Heterogeneity in meta-analyses of genome-wide association investigations

  18426861   Association analysis of type 2 diabetes Loci in type 1 diabetes

  18443202   Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies

  18461161   Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

  18533027   Worldwide population differentiation at disease-associated SNPs

  18591388   Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

  18633108   Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

  19008344   Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians

  19056611   Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data

  19096518   A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.

  19207020   Meta-analysis in genome-wide association studies

  19228808   Type 2 diabetes risk alleles are associated with reduced size at birth.

  19341491   Genome-based prediction of common diseases: methodological considerations for future research

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19526209   Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

  19592620   Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

  19602701   Underlying genetic models of inheritance in established type 2 diabetes associations

  19734549   Ranking of genome-wide association scan signals by different measures

  19741166   Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study

  19741467   Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

  19794065   Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes

  19862325   PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population

  19931040   Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies

  20017978   Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study

  20018066   Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study

  20043145   Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

  20080751   Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

  20161779   Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

  20424228   Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.

  20509872   Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

  20550665   Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20816152   Obesity and diabetes genetic variants associated with gestational weight gain.

  20862305   Identification of new genetic risk variants for type 2 diabetes.

  20886378   Physiologic characterization of type 2 diabetes-related loci

  20929593   The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI.

  21084393   Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.

  21150882   Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21297524   The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.

  21368910   Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

  21444075   Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

  21611789   The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.

  22052079   Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.

  22113416   Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study

  22237986   Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.

  22275441   Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans.

  22923468   Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.

  23013243   Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

  23073174   From genotype to human β cell phenotype and beyond

  23298195   Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.

  23577239   Genetics of obesity and type 2 diabetes in African Americans.

  24012816   The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: a meta-analysis.

  24604100   High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients.

  24653947   Cumulative Effect of Common Genetic Variants Predicts Incident Type 2 Diabetes: A Study of 21,183 Subjects from Three Large Prospective Cohorts.

  24736664   Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: a replication study and meta-analysis.

  24760768   Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human.

  24864266   Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.

  24926958   Evaluation of common type 2 diabetes risk variants in a South Asian population of Sri Lankan descent.

  24935819   Exploring genetic variants predisposing to diabetes mellitus and their association with indicators of socioeconomic status.

  24982668   Estimating the predictive ability of genetic risk models in simulated data based on published results from genome-wide association studies.

  25774817   Genetics of type 2 diabetes-pitfalls and possibilities.

  26119585   The CDKAL1 gene is associated with impaired insulin secretion and glucose-related traits: the Cardiometabolic Risk in Chinese (CRC) study.

  26168825   Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.

  26648684   Update on genetics and diabetic retinopathy.

  26789123   A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation.

  26873362   Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population.

  27139004   A Common Susceptibility Gene for Type 2 Diabetes Is Associated with Drug Response to a DPP-4 Inhibitor: Pharmacogenomic Cohort in Okinawa Japan.

  27275426   The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population.

  27383215   Type 2 Diabetes Risk Allele Loci in the Qatari Population.

  27589775   Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese.

  28359772   GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes.

  28717589   Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population.

  28821857   CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.

  29372795   [The analysis of association between type 2 diabetes and polymorphic markers in the CDKAL1 gene and in the HHEX/IDE locus].

  30185902   Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women.

  30907055   Effects of variants of 50 genes on diabetes risk among the Chinese population born in the early 1960s.

  31623129   Validation of Identified Susceptible Gene Variants for New-Onset Diabetes in Renal Transplant Recipients.

  31639799   A Novel Polymorphism (rs35612982) in CDKAL1 Is a Risk Factor of Type 2 Diabetes: A Case-Control Study.

  32273741   SLC30A8, CDKAL1, TCF7L2, KCNQ1 and IGF2BP2 are Associated with Type 2 Diabetes Mellitus in Iranian Patients.

  32791750   Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis.

  33170928   Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People.

  33447064   Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population.

  34977253   Association of CDKAL1 RS10946398 Gene Polymorphism with Susceptibility to Diabetes Mellitus Type 2: A Meta-Analysis.