SNP information rs1801278

Research and publications:

  1311924   Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma.

  7623569   Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

  8104271   Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

  8647950   A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.

  10084586   Prevalence of variants in candidate genes for type 2 diabetes mellitus in The Netherlands: the Rotterdam study and the Hoorn study.

  10430617   The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.

  10591678   A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.

  10843189   The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.

  12843189   The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.

  14671192   Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.

  14707024   G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.

  15240653   Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.

  17570749   Genetic prediction of future type 2 diabetes

  18398029   Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.

  18398040   Transcription factor 7-like 2 polymorphism and colon cancer

  18599530   Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18992148   Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study

  18992263   Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways

  19124510   Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma

  19843326   Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.

  19956100   No association of the IRS1 and PAX4 genes with type I diabetes.

  19956101   Overview of the Rapid Response data

  19956109   Type I Diabetes Genetics Consortium Rapid Response Family-Based Candidate Gene Study: Strategy, Gene Selection, and Key Findings.

  20081858   New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  20392289   Genetic associations in type I interferon related pathways with autoimmunity.

  20416077   Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

  20452482   Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

  21442158   Genetic variants near the IRS1 gene, physical activity and type 2 diabetes in US men and women.

  21544032   Genetic and clinical risk factors of new-onset diabetes after transplantation in Hispanic kidney transplant recipients.

  21645940   The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status.

  21747906   Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans.

  21819567   Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins.

  21834909   A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico.

  22617042   The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling.

  22729394   A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.

  23107043   Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.

  23133645   The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.

  23633196   Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

  23690305   Genetic variants and the risk of gestational diabetes mellitus: a systematic review

  23708959   Association between insulin receptor substrate 1 Gly972Arg polymorphism and cancer risk.

  23946381   Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.

  24071662   The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.

  24309190   Genetics of new-onset diabetes after transplantation.

  24493031   Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population.

  24589556   Insulin receptor substrate-1 polymorphism Arg972, risk and severity of Alzheimer's disease.

  24612564   Association of IRS1, CAPN10, and PPARG gene polymorphisms with type 2 diabetes mellitus in the high-risk population of Hyderabad, India.

  25146448   Relationship between melatonin receptor 1B and insulin receptor substrate 1 polymorphisms with gestational diabetes mellitus: a systematic review and meta-analysis.

  25185137   Contribution of genetic background and antiretroviral therapy to body fat changes in antiretroviral-naive HIV-infected adults.

  25266237   Genetic association study between INSULIN pathway related genes and high myopia in a Han Chinese population.

  25424426   Arg972 insulin receptor substrate-1 polymorphism and risk and severity of rheumatoid arthritis.

  25557790   An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women.

  26042206   Gene-gene and gene-environment interactions in the etiology of type 2 diabetes mellitus in the population of Hyderabad, India.

  26334876   CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population.

  26349669   Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/obese subjects.

  26810132   Genetic markers predicting sulphonylurea treatment outcomes in type 2 diabetes patients: current evidence and challenges for clinical implementation.

  27005817   Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus.

  27144430   Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX.

  27314342   A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence.

  27347941   Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes.

  27376028   Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk.

  27468700   Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis.

  27547017   Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.

  27657051   Molecular Pathogenesis of NASH.

  28360393   Single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 genes in the pathogenesis of polycystic ovary syndrome.

  28369940   Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial.

  28696414   Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus.

  29256014   Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort.

  29340108   Effect of gene-lifestyle interaction on gestational diabetes risk.

  29622662   Potential genetic polymorphisms predicting polycystic ovary syndrome.

  30319284   IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance.

  30515958   Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine.

  30649085   The effects of genetic variants related to insulin metabolism pathways and the interactions with lifestyles on colorectal cancer risk.

  31446532   Genetic association of insulin receptor substrate-1 (IRS-1, rs1801278) gene with insulin resistant of type 2 diabetes mellitus in a Pakistani population.

  31704287   Genetic variants in mTOR-pathway-related genes contribute to osteoarthritis susceptibility.

  32326111   Role of Genetic Variations in the Hepatic Handling of Drugs.

  32930968   Pharmacogenomic Studies of Current Antidiabetic Agents and Potential New Drug Targets for Precision Medicine of Diabetes.

  33895751   The Association between Maternal/Fetal Insulin Receptor Substrate 1 Gene Polymorphism rs1801278 and Gestational Diabetes Mellitus in a Chinese Population.

  34803393   Pharmacogenomics and Personalized Medicine in Type 2 Diabetes Mellitus: Potential Implications for Clinical Practice.

  36011374   Insulin Receptor Substrate 1 Gly972Arg (rs1801278) Polymorphism Is Associated with Obesity and Insulin Resistance in Kashmiri Women with Polycystic Ovary Syndrome.