SNP information rs780094

Research and publications:

  17903299   A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

  18008060   The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.

  18179892   Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

  18193044   Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

  18439548   Loci associated with metabolic syndrome pathways, including LEPR, HNF1A, IL6R, and GCKR, are associated with plasma C-reactive protein: the Women's Genome Health Study.

  18439552   Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

  18521185   Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

  18556336   The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  18596051   Polygenic determinants of severe hypertriglyceridemia.

  18678614   Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

  18852197   Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

  19056598   Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.

  19060907   Variants in MTNR1B influence fasting glucose levels

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19060911   Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

  19068216   Investigation of Crohn's disease risk loci in ulcerative colitis further determines their molecular relatedness.

  19073768   Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

  19096518   A novel association of HK1 with glycated hemoglobin in a nondiabetic population: a genome-wide assessment of 14,618 Women's Genome Health Study participants.

  19111066   Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

  19148283   Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

  19161620   An open access database of genome-wide association results

  19197348   Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

  19241058   Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.

  19336475   Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk

  19435741   Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19503597   Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

  19533084   Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

  19651813   Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits

  19656773   A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

  19679263   Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.

  19802338   Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicatio

  19822575   Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

  19861489   Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.

  19890391   Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.

  19937311   Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations

  20017967   Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.

  20031577   New loci, including those associated with Crohn's disease, psoriasis and inflammation, were identified in a genome-wide association study of fibrinogen in 17,686 women: the Women's Genome Health Study.

  20043853   Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

  20081857   Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

  20081858   New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  20152958   A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels

  20161779   Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort

  20162742   Predictive value of 8 genetic loci for serum uric acid concentration.

  20162743   Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.

  20185807   Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20352598   Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study.

  20502693   Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

  20574426   The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.

  20583287   Analyze multivariate phenotypes in genetic association studies by combining univariate association tests.

  20625834   Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.

  20628598   Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects

  20661421   Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.

  20668700   Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion

  20691829   Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.

  20693352   Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20805255   Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population

  20820957   The Genetics of Insulin Resistance: Where's Waldo?

  20831840   Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned.

  20838585   Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.

  20839289   Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose

  20858683   Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.

  20870969   Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study

  20886378   Physiologic characterization of type 2 diabetes-related loci

  21036910   Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study

  21041806   Genetic determinants of plasma triglycerides.

  21091714   The genetics of type 2 diabetes: what have we learned from GWAS?

  21114848   GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?

  21149302   Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population.

  21188353   Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans

  21194676   Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21288825   Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21318467   Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women.

  21378175   Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program

  21386085   A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.

  21411509   Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.

  21421807   Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

  21423719   Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

  21441441   Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21515849   Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children

  21527746   Triglycerides and heart disease: still a hypothesis?

  21569451   Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.

  21643755   Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients.

  21674002   Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome.

  21700865   Human fatty liver disease: old questions and new insights

  21738485   Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

  21767357   Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome.

  21768215   Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.

  21799482   Common genetic variants and central adiposity among Asian-Indians.

  21799836   A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.

  21804106   Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

  21810599   Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis

  21829377   Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.