Upload the DNA data file of the test

23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage

and get an enhanced
personalized health report
free without registration

Files accepted .txt, .csv, .zip, .csv.gz

File data is not stored on the server

SNP information rs10830963

RS10830963

Normal allele: CC

common variant MTNR1B, which encodes melatonin receptor 1B, increases the risk of impaired fasting glycaemia and type 2 diabetes due to impaired glucose-stimulated insulin release. The findings suggest that carriers of the G allele rs10830963 may have greater improvement in obesity and body fat distribution when following a low-fat diet.

Polymorphism rs10830963 is related to topics like this:

INSR Gene Insulin Receptor

The gene known as INSR directs the production of insulin receptors - proteins present in various...

Low fat diet genetic

The American Heart Association (AHA) suggests a low-fat diet as a healthy eating practice, which...

Research and publications:

  19060907   Variants in MTNR1B influence fasting glucose levels

  19088850   Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

  19184136   Examination of association of genes in the serotonin system to autism

  19241057   A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

  19324937   Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults

  19324940   G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

  19455304   Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response

  19502414   Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men

  19533084   Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

  19651812   Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians

  19651813   Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits

  19734549   Ranking of genome-wide association scan signals by different measures

  19741166   Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study

  19808892   Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

  19822575   Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

  19833888   Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

  19937311   Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations

  20037589   A genome-wide perspective of genetic variation in human metabolism

  20043853   Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

  20081858   New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  20152958   A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels

  20159871   Association between a literature-based genetic risk score and cardiovascular events in women

  20185807   Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

  20200315   MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

  20203524   Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk

  20398260   MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai

  20628598   Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects

  20664687   Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract

  20668700   Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion

  20693352   Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

  20712903   Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study

  20802253   Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20805255   Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population

  20839289   Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose

  20870969   Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study

  20886378   Physiologic characterization of type 2 diabetes-related loci

  20959387   Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome

  20980412   Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study

  21036910   Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study

  21059861   Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS

  21071884   An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies

  21091714   The genetics of type 2 diabetes: what have we learned from GWAS?

  21103332   Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies

  21103350   Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese

  21152029   Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function

  21188353   Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans

  21278902   Genetic risk profiling for prediction of type 2 diabetes

  21366812   Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents

  21378175   Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program

  21380592   No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study

  21421807   Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

  21441441   Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort

  21470412   A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals

  21515849   Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children

  21558052   A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity

  21711391   Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany

  21810599   Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis

  21860691   Role of melatonin on diabetes-related metabolic disorders

  21887289   Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin

  21949744   Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes

  21975967   Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes care

  22038522   Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism

  22046406   Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese

  22096510   Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population

  22113416   Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study

  22138747   Melatonin pathway genes and breast cancer risk among Chinese women

  22233651   A genome-wide association study of gestational diabetes mellitus in Korean women

  22245784   Melatonin membrane receptors in peripheral tissues: distribution and functions

  22307069   Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial

  22377712   Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

  22508271   Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA)

  22546499   Genome-wide association studies with metabolomics

  22695700   The genetic epidemiology of idiopathic scoliosis

  22698518   Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients

  22708638   Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial

  22724080   Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment

  22759724   Polymorphisms in the melatonin receptor 1B gene and the risk of delirium

  22768041   Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals

  22768333   Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women

  22972380   Investigation of genetic risk factors for chronic adult diseases for association with preterm birth

  22984506   Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program

  23013243   Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

  23029294   Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus

  23073174   From genotype to human β cell phenotype and beyond

  23092954   SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits

  23185617   Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants

  23193118   Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium

  23251661   Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population

  23456907   Maternal genotype and gestational diabetes

  23462794   Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

  23611530   Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines

  23690305   Genetic variants and the risk of gestational diabetes mellitus: a systematic review

  23761423   Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

  23971978   Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

  24335056   Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets: the POUNDS LOST Trial

  24637646   Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese

  24710643   Effects of melatonin receptor 1B gene variation on glucose control in population from Bosnia and Herzegovina

  24728128   Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans

  24845081   Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

Tuberculosis genes

The bacterium Mycobacterium tuberculosis is the culprit behind Tuberculosis, an infectious disease....

Diabetes genes

Diabetes mellitus is marked by a complex interplay of genetic, epigenetic, and environmental...

Glaucoma is it hereditary

Hereditary primary open-angle glaucoma is the prevailing kind of glaucoma. If any of your immediate...

List of all diseases
en
|
de
|
fr
|
es
|
it
|
ua
|
ru

About

Documents

Support