SNP information rs3024505

Research and publications:

  18836448   Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.

  19430480   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19505919   Toll-like receptor signaling pathway variants and prostate cancer mortality

  19698145   Replication by the Epistasis Project of the interaction between the IL-6 and IL-10 genes in Alzheimer's disease risk.

  19776214   SimCT: a generic tool to visualize ontology-based relationships for biological objects

  19838195   A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  19915574   Common variants at five new loci associated with early-onset inflammatory bowel disease.

  20176734   Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20441431   Recent advances in the genetics of systemic lupus erythematosus.

  20444268   Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

  20509889   The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

  20587799   Genetics of type 1 diabetes: what next?

  20622878   Genome-wide association study identifies variants in MHC class I regions, IL10 and IL23R-IL12RB2, associated with Behçet's disease.

  20716621   Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20848476   Genetic predictors of medically refractory ulcerative colitis.

  20885991   Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  21102463   Genome-wide meta-analysis increases the number of confirmed susceptibility loci for Crohn's disease to 71.

  21245992   Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease.

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21354456   Impact of genetic variation in IL-10 and serum interleukin 10 levels on susceptibility to Crohn's disease in a New Zealand population.

  21379322   Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.

  21408207   Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21565292   Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies.

  21682861   Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  21980299   A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

  21995314   Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study.

  22046141   Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

  22278338   Confirmation of novel type 1 diabetes risk loci in families.

  22291604   A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.

  22336179   IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme.

  22396665   Interpreting meta-analyses of genome-wide association studies.

  22493750   Interactions between PPAR-β and inflammation-related cytokine genes in the development of Alzheimer's disease observed by the Epistasis Project.

  22536486   Lupus nephritis: an overview of recent findings.

  22594912   Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study.

  22654485   Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.

  22674296   Interleukin genes and associations with colon and rectal cancer risk and overall survival.

  22753952   Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

  22844404   Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers.

  22988944   Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases.

  23028907   Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.

  23280621   Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

  23348120   Genetic predisposition to IBD: overlap between ulcerative colitis and Crohn's disease.

  23804261   From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.

  24502445   Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery.

  24889212   Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.

  24971461   Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.

  25034154   Clinical perspectives on lupus genetics: advances and opportunities.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25369137   A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.

  25491747   Interactions between meat intake and genetic variation in relation to colorectal cancer.

  26732016   Collecting Biospecimens From an Internet-Based Prospective Cohort Study of Inflammatory Bowel Disease (CCFA Partners): A Feasibility Study.

  26904692   Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27417569   Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases.

  27906046   Chromatin landscapes and genetic risk in systemic lupus.

  28056976   A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

  29070082   Sex influences eQTL effects in SLE and genetic polymorphisms associated with Sjögren's syndrome.

  29487192   Association of interleukin-10 gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population.

  29566186   Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study.

  30568945   Genetic associations of inflammatory bowel disease in a South Asian population.

  30801121   Unresolved association of genetic markers and progression of Crohn's disease: experience from a North American cohort.

  30882006   STAT4, TRAF3IP2, IL10 and HCP5 polymorphisms in Sjögren's syndrome: association with disease susceptibility and clinical aspects.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  31052430   Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients.

  31085105   Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.

  31129315   Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.

  31217170   Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals.

  31605784   Genetic predictors of long-term response and trough levels of infliximab in Crohn's disease.

  31651650   Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population.

  34628128   Association between IL-10 rs3024505 and susceptibility to inflammatory bowel disease: A systematic review and meta-analysis.

  34888949   Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population.