SNP information rs2104286

Research and publications:

  18224336   Haplotypic analysis of Wellcome Trust Case Control Consortium data.

  18274536   Genome-wide association studies: progress and potential for drug discovery and development.

  18354419   IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.

  18490360   The complex genetics of multiple sclerosis: pitfalls and prospects.

  18565446   Refining genetic associations in multiple sclerosis.

  18650830   Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.

  18794857   Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  19116909   Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.

  19119414   IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

  19125193   IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

  19155502   Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.

  19265545   Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.

  19375175   Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.

  19525953   Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

  19546505   IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).

  19565500   Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

  19701192   Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

  19865102   Multiple sclerosis susceptibility alleles in African Americans.

  19956099   The type I diabetes association of the IL2RA locus.

  19956101   Overview of the Rapid Response data

  19956106   Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

  20007504   Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.

  20017963   Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

  20075733   Recent advances in the genetics of rheumatoid arthritis.

  20179739   Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.

  20182566   The genetic aspects of multiple sclerosis.

  20186855   What role for genetics in the prediction of multiple sclerosis?

  20219786   The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

  20309874   Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

  20362271   Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

  20362272   Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come.

  20368992   Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.

  20405052   The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20461788   Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients.

  20498205   Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.

  20510233   Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20810507   Influence of IL2RA rs2104286 polymorphism in the risk of biopsy-proven giant cell arteritis.

  21029420   The genetic basis of multiple sclerosis: a model for MS susceptibility.

  21151127   Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

  21239413   Association of IL2RA polymorphisms with susceptibility to multiple sclerosis is not explained by missense mutations in IL2RA.

  21247752   Revealing the genetic basis of multiple sclerosis: are we there yet?

  21280076   Aggregation of multiple sclerosis genetic risk variants in multiple and single case families.

  21368773   Peripheral blood gene expression profiles in metabolic syndrome, coronary artery disease and type 2 diabetes.

  21629267   Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

  21815908   The Il2raâ/âCd25 gene variant, which predisposes to Graves' disease, is associated with increased levels of soluble interleukin-2 receptor.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  21873553   Genetic analysis of adult-onset autoimmune diabetes.

  21911588   IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?

  21963258   Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets.

  22085902   Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

  22164203   Perspectives on the use of multiple sclerosis risk genes for prediction.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22211793   Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population.

  22294642   Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.

  22328738   Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

  22355377   Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians.

  22496761   Improving power of genome-wide association studies with weighted false discovery rate control and prioritized subset analysis.

  22654554   Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.

  22661644   Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

  23121884   Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

  23529819   Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis.

  23730204   Progress in multiple sclerosis genetics.

  23804261   From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.

  24041540   Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.

  24068971   Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.

  24332945   Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese.

  24367383   Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young.

  24449572   Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

  24670917   Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.

  24751721   Mannose binding lectin and susceptibility to rheumatoid arthritis in Brazilian patients and their relatives.

  24770783   Genetic variants in IL2RA and IL7R affect multiple sclerosis disease risk and progression.

  24931268   The role of functional polymorphisms in immune response genes as biomarkers of bacille Calmette-Guérin (BCG) immunotherapy outcome in bladder cancer: establishment of a predictive profile in a Southern Europe population.

  25061809   Analyzing genome-wide association studies with an FDR controlling modification of the Bayesian Information Criterion.

  25137520   Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions.

  25328554   Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.

  25347332   Interleukin-2 and its soluble receptor alpha subunit in autoimmune Addison's disease—an association study and expression analysis.

  25777745   Recent advances in the genetics of systemic sclerosis: toward biological and clinical significance.

  25964488   GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.

  26092158   IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups.

  26106387   Pathogenesis of Systemic Sclerosis.

  26106896   Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

  26249556   Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies.

  26350950   IL2RA is associated with persistence of rheumatoid arthritis.

  26765264   The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.

  27047537   Using Incomplete Trios to Boost Confidence in Family Based Association Studies.

  27331016   ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese.

  27896277   Prediction of Bacillus Calmette-Guerin Response in Patients with Bladder Cancer after Transurethral Resection of Bladder Tumor by Using Genetic Variation Based on Genomic Studies.

  28139605   Analysis of the relationship between cytokine receptor gene polymorphisms and clinical features of multiple sclerosis.

  28511943   Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis.

  29648897   Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk.

  30352019   A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  31242590   Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls.

  31297130   C6orf10 Low-Frequency and Rare Variants in Italian Multiple Sclerosis Patients.