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Is OCD obsessive compulsive disorder genetic

ocd

By Li Dali, Ph.D.

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by features known as obsessions and compulsions. Obsessions refer to intrusive thoughts, mental images or urges that compel an individual to perform specific actions. Although these obsessions can vary extensively, they often include fear of illness or contamination; a desire for symmetry or getting things "just right;" or intrusive thoughts involving religion, sex, or aggression. On the other hand,true text Compulsions involve repetitive performance beholden certain behaviors such checking and verifying,washing,counting,arranging ,acting out specific routines,and seeking assurance.These acts aim at relieving anxiety ((comma needed)) rather than serving pleasure like gambling,eating hurriedly,kleptomania etc

Although almost everybody experiences obsessive feelings and compulsive behaviors at times or in specific situations, with OCD they last for more than an hour each day and lead to issues at work, school, or socially. Those individuals suffering from OCD typically feel anxiety and other distress due to their need of catering towards their obsessions or compulsions.

Obsessive-compulsive disorder (OCD) is a severe psychiatric illness that affects around 2% of both children and adults' populations. Family aggregation studies have demonstrated OCD's familial nature, while twin studies show that its heredity partly results from genetic factors.

Obsessive-compulsive disorder (OCD) can be hereditary, yet it does not necessarily mean that you will acquire the condition if a family member has it. Environmental factors also significantly contribute to its development, and both genetic predisposition and environmental influences play an interactive role in determining whether or not you may develop OCD at some point. Continue reading to discover more about how genes might affect your chances of developing OCD and how these elements could interact with various risks present in your surroundings.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Obsessive-compulsive disorder (OCD) and see a list of existing studies.

SNP polymorphisms related to the topic Obsessive-compulsive disorder (OCD):

rs1799913Variants in the tryptophan hydroxylase gene involved in the development and treatment of opiate, heroin and cocaine addiction.
rs6313TPH-2 polymorphisms affect response to treatment with antidepressants and SSRIs.
rs4570625The TPH2 gene variant is associated with attention-deficit/hyperactivity disorder.
rs4680The study showed a 10% increase in total plasma homocysteine (tHcy)
rs25531The serotonin transporter rs25531 polymorphism is associated with neuroticism, depression, OCD, ADHD and autism spectrum disorder.
rs6314The serotonin receptor gene HTR2A polymorphism is associated with bipolar affective disorder and autism spectrum disorder.
rs1805476The glutamate receptor gene GRIN2B associated with reduced glutamatergic concentration in the anterior cingulate cortex in obsessive-compulsive disorder in children.
rs17110563The gene breakage is linked to bipolar affective disorder.
rs1125394The DRD2 polymorphism modulates reward and emotion processing, dopamine neurotransmission, and openness to experience.
rs167771The dopamine receptor-3 (DRD3) gene is associated with specific repetitive behaviours in autism spectrum disorders.
rs4648317Tendency to higher nicotine dependence, increased impulsivity and thrill-seeking.
rs6305Serotonin transporter and serotonin receptor gene polymorphisms are associated with susceptibility to substance abuse.
rs3742278Serotonin receptor gene HTR2A polymorphism is associated with panic disorder features.
rs1928040Polymorphisms of the gene encoding serotonin 2A receptor affect response to antidepressant treatment.
rs6265Increased risk of ADHD or depression. Slightly faster decline in mental abilities in patients with Alzheimer's disease. The presence of this BDNF polymorphism is associated with differences in brain motor system functioning, altered short-term plasticity, and greater error in short-term motor learning.
rs890Glutamate receptor gene (GRIN2B) associated with reduced glutamatergic concentration in the anterior cingulate gyrus in obsessive-compulsive disorder in children.
rs6311Genetic factors specific to obsessive-compulsive disorder.
rs2283265Functional variants of the dopamine receptor gene are a potential factor in neuropsychiatric disorders.
rs1062613Fear reactivation and symptoms of combat-related PTSD: specificity and preliminary study of the effect of the 5-HT3A receptor gene.
rs25532Each C rs25532 allele accounts for increased serotonin transporter function and is pathogenetically associated with OCD.
rs1176713Common variants of the HTR3 gene are associated with obsessive-compulsive disorder.
rs9325202Breakage of the tryptophan hydroxylase gene promotes dishonest behaviour.
rs1843809Breakage of the tryptophan hydroxylase 2 (TPH2) gene associated with attention deficit hyperactivity disorder.
rs7997012Associations of the serotonin receptor gene HTR2A with bipolar disorder and major depressive disorder.
rs7224199Association with major depression and response to antidepressants. The polymorphism is associated with selective serotonin and serotonin-norepinephrine reuptake inhibitor response in depressive disorder.
rs3780412Association of the glutamate transporter gene SLC1A1 with atypical obsessive-compulsive symptoms induced by neuroleptics.
rs2228622Association between the SLC1A1 gene and early onset of obsessive-compulsive disorder.
rs301443Association between the glutamate transporter gene SLC1A1 and early onset of obsessive-compulsive disorder.
rs6277Associated with a 1.6-fold increased risk of schizophrenia.
rs140700A variant of the serotonin transporter gene (SLC6A4) is associated with suicidal behaviour in schizophrenic patients.
rs28914829A polymorphism in the serotonin transporter locus (SLC6A4) predisposes to autism and compulsive rigid behaviour.
rs3087879A haplotype containing quantitative trait loci of SLC1A1 gene expression is associated with obsessive-compulsive disorder.
rs16965628A genetic polymorphism of the serotonin transporter gene, SLC6A4 rs16965628, is associated with obsessive-compulsive disorder.
rs2066713A functional serotonin transporter gene polymorphism is associated with major depression, schizophrenia and ADHD.
rs270722-fold risk of severe alcohol withdrawal. Associated with more severe symptoms after alcohol withdrawal, such as seizures and white fever. Possible increased chance of ADHD.
rs6267
rs6296
rs165631
rs211107
rs220597
rs297941
rs301430
rs460000
rs676643
rs737865
rs737866
rs769224
rs849876
rs1019385
rs1081003
rs1232487
rs1568214
rs1805088
rs1805502
rs1806202
rs2039290
rs2150195
rs2160734
rs2268102
rs2300252
rs2617605
rs2734838
rs3177118
rs3737193
rs3773678
rs3776512
rs3780413
rs3780415
rs4460839
rs4565946
rs4742007
rs4764011
rs5993883
rs7022772
rs7124442
rs7297761
rs7298664
rs7848533
rs9316232
rs9332316
rs9332377
rs9499708
rs9567737
rs9652236
rs9824856
rs10232398
rs10499905
rs10748189
rs10814991
rs10835210
rs10879346
rs10974584
rs10974587
rs11214606
rs11657536
rs12579598
rs12583882
rs16921385
rs17834128
rs28363168
rs28371725
rs35815285
rs56232120
rs61888800
rs116567227
rs1057519438

About The Author
Li Dali Li Dali

Li Dali, a National Foundation for Outstanding Youth Fund recipient, is a researcher at the School of Life Sciences in East China Normal University. He earned his PhD in genetics from Hunan Normal University in 2007 and conducted collaborative research at Texas A&M University during his doctoral studies. Li Dali and his team have optimized and innovated gene editing technology, leading to the establishment of a world-class system for constructing gene editing disease models.

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