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Genetics and atherosclerosis

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Atherosclerosis is a progressive inflammatory disorder that underlies coronary artery disease (CAD) and stroke - major causes of worldwide mortality and morbidity. To gain in-depth knowledge about the biology of this disease, numerous recent reviews are available1-3. Most understanding on factors contributing to atherosclerosis comes from epidemiological studies and Mendelian investigations into forms like familial hypercholesterolemia; these reveal important roles played by plasma lipoprotein, blood pressure issues, diabetes-related risk factors as well as other risks. Elaboration around pathways/mechanisms involved rely mostly on animal models primarily genetically engineered hypercholesterolemic mice4,5. The vast majority preventing CAD & stroke involves complex genetic/environmental considerations which previously presented challenges with regards genetic dissection but would be beneficial when assessing common forms6: gaining insights into their detailed mechanistic understanding could have significant treatment/ prevention implications for those experiencing symptoms associated with Atherosclerosis..

Researchers have discovered that the gene SVEP1 produces a protein which fuels the growth of plaque in arteries. In mice, those without one copy of SVEP1 had less arterial plaque than those with both copies.

By using mouse models and analyzing human genetic data, the researchers have observed that there is a correlation between genetic variation affecting levels of this protein in the body and an increased risk for developing plaque build-up within arteries.

SVEP1 is required for the early development of embryos. However, removing the protein in adult mice did not appear to be harmful according to researchers.

Their findings pave a new path for potential treatments of coronary artery disease and may lead to further strategies targeting or blocking the gene.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Atherosclerosis and see a list of existing studies.

SNP polymorphisms related to the topic Atherosclerosis:

rs2229116The RYR3 gene variant is associated with an increased risk of carotid atherosclerosis in immunocompromised individuals.
rs1878406The rs1878406 polymorphism of the endothelin receptor gene is associated with severe multivessel coronary artery disease.
rs4712972The renal urate transporter SLC17A1 polymorphism is associated with the occurrence of carotid artery plaques.
rs6511720Low-density lipoprotein receptor polymorphisms are associated with risk of atherosclerotic vascular disease.
rs1856746Breakdown increases the risk of coronary atherosclerosis.
rs9632884Association of the 9p21-3 locus with coronary atherosclerosis and coronary heart disease.
rs958994
rs17691394
rs17151904
rs1697137
rs588517
rs13053817
rs147555597
rs9727451
rs11413744
rs4779614
rs259140
rs17045031
rs445925
rs17398575
rs11781551
rs6601530
rs11726269
rs682112
rs2526620
rs118039278
rs8003602
rs10841443
rs9515203
rs112043140
rs2822693
rs1108775
rs2791713
rs291096
rs11012265
rs17366136
rs10830090
rs17078595
rs6894083
rs890710
rs1035208
rs6900057
rs12285326
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