Upload the DNA data file of the test

23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage

and get an enhanced
personalized health report
free without registration

Files accepted .txt, .csv, .zip, .csv.gz

File data is not stored on the server

SNP information rs6265


Normal allele: CC

Increased risk of ADHD or depression. Slightly faster decline in mental abilities in patients with Alzheimer's disease. The presence of this BDNF polymorphism is associated with differences in brain motor system functioning, altered short-term plasticity, and greater error in short-term motor learning.

Polymorphism rs6265 is related to topics like this:

Empath genetics

According to the researchers, genetics play a role in our ability to comprehend and react...

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...

Is OCD obsessive compulsive disorder genetic

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by features known as...

Depression is it genetic

Depression, also referred to as major depression or major depressive disorder, is a psychiatric...

ADHD is it genetic

ADHD, a behavioral disorder that usually commences during childhood, is marked by a brief attention...

Research and publications:

  12140781   Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor

  12161822   The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study

  12553913   The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

  12836135   Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder

  12888803   Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type

  15115760   Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations

  15337662   Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype

  15457498   Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder

  16005437   Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression

  16152572   Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder

  16172806   The role of the G196A polymorphism in the brain-derived neurotrophic factor gene in the development of Parkinson's disease: a meta-analysis

  16222333   Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder

  16344533   BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

  16389585   The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study

  16497333   No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults

  16631352   No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population

  16741941   Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate

  16962786   Brain-derived neurotrophic factor does not influence the age of neurological onset of Huntington's disease.

  17096834   No association between polymorphisms in the BDNF gene and age at onset in Huntington disease

  17135278   Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

  17196936   Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis

  17212826   TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.

  17219016   No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD

  17293537   Brain-derived neurotrophic factor genetic variants associated with Alzheimer's disease.

  17417060   Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder

  17483451   Gene-gene interaction associated with neural reward sensitivity

  17503330   A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.

  17602759   Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis

  17632285   The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans

  17653045   Candidate gene and locus analysis of myopia

  17656372   Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor

  17657167   Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population

  17894414   BDNF Val66Met variant and age of onset in schizophrenia.

  17918236   Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder

  18205169   Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis

  18478177   Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine

  18534558   Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.

  18565990   Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

  18600033   Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18704161   Genetic variation in an individual human exome.

  18776599   Susceptibility genes for gentamicin-induced vestibular dysfunction.

  18779388   Assessing the potential for excess of statistically significant results in published genetic association studies: Application to Alzheimer's disease.

  18813964   Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

  18830724   Assessing case-control associations of Alzheimer's disease using family-based methods.

  18852698   Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

  18957941   Genome-wide association scan for five major dimensions of personality.

  19018231   Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder

  19018715   Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients

  19209189   Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

  19236730   Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response

  19258022   Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.

  19295238   Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families

  19330778   Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population

  19336781   Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.

  19359258   Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

  19388013   BDNF, relative preference, and reward circuitry responses to emotional communication

  19403460   Pharmacogenetics of antidepressant response: an update.

  19412541   Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects

  19414708   Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.

  19424874   Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population

  19461660   No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

  19478790   The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

  19530966   Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis

  19582215   Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray

  19582565   Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder

  19603419   Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations

  19699537   Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent.

  19721723   Brain-derived neurotrophic factor: role in depression and suicide.

  19721846   Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants

  19734545   A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.

  19797905   Allelic based gene-gene interaction in case-control studies

  19844571   Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities

  19895626   The effect of BDNF gene variants on asthma in German children

  19925205   Ebbinghaus revisited: influences of the BDNF Val66Met polymorphism on backward serial recall are modulated by human aging

  19940176   Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.

  19944766   A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia

  19953912   [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders]

  20004415   Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene

  20008943   Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

  20014955   Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression

  20016225   Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients

  20033742   Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population

  20042999   BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism

  20075215   A genetic variant BDNF polymorphism alters extinction learning in both mouse and human

  20087404   Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study

  20124106   Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients

  20125193   Common genetic variation and performance on standardized cognitive tests.

  20127379   From monogenic to polygenic obesity: recent advances.

  20147969   Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension

  20159343   The genetics of major depression: moving beyond the monoamine hypothesis.

  20172611   Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder

  20191112   The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.

  20226536   Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.

  20400928   Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR

  20418890   Genome-wide meta-analyses identify multiple loci associated with smoking behavior

  20426150   Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture

  20456319   Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia.

  20478698   Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study

  20482942   Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory

DNA oxidation

Cancer may be linked to oxidative damage of DNA from various chemical and physical agents, but...

Omega 3 genetics

It may seem counterintuitive that substances with the names "fat" and "acid" can be beneficial for...

CPT2 disease

A condition affecting the oxidation of long-chain fatty acids, Carnitine palmitoyltransferase II...