Normal allele: CC
Increased risk of ADHD or depression. Slightly faster decline in mental abilities in patients with Alzheimer's disease. The presence of this BDNF polymorphism is associated with differences in brain motor system functioning, altered short-term plasticity, and greater error in short-term motor learning.
Polymorphism rs6265 is related to topics like this:
Oxytocin and empathyDopamineObsessive-compulsive disorder (OCD)DepressionADHD (Attention Deficit Hyperactivity Disorder)
Research and publications:
12140781 Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor
12161822 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study
12553913 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
12836135 Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder
12888803 Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type
15115760 Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
15337662 Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype
15457498 Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder
16005437 Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression
16152572 Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder
16172806 The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysis
16222333 Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder
16344533 BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study
16389585 The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study
16497333 No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
16631352 No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population
16741941 Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate
16962786 Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease
17096834 No association between polymorphisms in the BDNF gene and age at onset in Huntington disease
17135278 Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
17196936 Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis
17212826 TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.
17219016 No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD
17293537 Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease
17417060 Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder
17483451 Gene-gene interaction associated with neural reward sensitivity
17503330 A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
17602759 Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis
17632285 The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans
17653045 Candidate gene and locus analysis of myopia
17656372 Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor
17657167 Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population
17894414 BDNF Val66Met variant and age of onset in schizophrenia.
17918236 Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder
18205169 Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
18478177 Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine
18534558 Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
18565990 Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence
18600033 Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients
18698231 Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
18704161 Genetic variation in an individual human exome.
18776599 Susceptibility genes for gentamicin-induced vestibular dysfunction.
18779388 Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease
18813964 Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta
18830724 Assessment of Alzheimer's disease case-control associations using family-based methods
18852698 Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
18957941 Genome-wide association scan for five major dimensions of personality.
19018231 Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder
19018715 Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients
19209189 Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI
19236730 Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response
19258022 Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
19295238 Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families
19330778 Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population
19336781 Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.
19359258 Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
19388013 BDNF, relative preference, and reward circuitry responses to emotional communication
19403460 Pharmacogenetics of antidepressant response: an update.
19412541 Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
19414708 Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.
19424874 Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population
19461660 No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
19478790 The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
19530966 Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis
19582215 Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray
19582565 Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder
19603419 Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations
19699537 Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent.
19721723 Brain-derived neurotrophic factor: role in depression and suicide.
19721846 Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants
19734545 A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
19797905 Allelic based gene-gene interaction in case-control studies
19844571 Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities
19895626 The effect of BDNF gene variants on asthma in German children
19925205 Ebbinghaus revisited: influences of the BDNF Val66Met polymorphism on backward serial recall are modulated by human aging
19940176 Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
19944766 A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
19953912 [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders]
20004415 Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene
20008943 Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
20014955 Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression
20016225 Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients
20033742 Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population
20042999 BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
20075215 A genetic variant BDNF polymorphism alters extinction learning in both mouse and human
20087404 Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study
20124106 Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
20125193 Common genetic variation and performance on standardized cognitive tests.
20127379 From monogenic to polygenic obesity: recent advances.
20147969 Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension
20159343 The genetics of major depression: moving beyond the monoamine hypothesis.
20172611 Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder
20191112 The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
20226536 Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
20400928 Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR
20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior
20426150 Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture
20456319 Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia.
20478698 Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study
20482942 Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory