Omega 3 genetics
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It may seem counterintuitive that substances with the names "fat" and "acid" can be beneficial for your health, but omega-3 fatty acids are essential when it comes to keeping your heart in good shape. These polyunsaturated fats must come from either supplements or a balanced diet because they're indispensable to everyone's well-being. In cases where you have an insufficient level of this kind of fat, there might arise some food limitations which should be taken into account. By using AncestryDNA®+Traits service, you will learn if potentially existing genetic factors could play a minor role in determining the levels of Omega 3s found in your body systems.
The quantity of omega-3s in your body relies heavily on your diet as these essential fatty acids are primarily obtained from food.
According to research, genes also have a minor influence. AncestryDNA examines the genes that impact four of the 11 recognized variations of omega-3s. Currently, only two genetic indicators are believed to moderately affect omega-3 levels: The ELOVL2 gene on chromosome 6 and the FADS1 gene on chromosome 11.
Despite having made some progress, genetics and nutrition research remains at an early stage. Scientists may still not have discovered all genes that are linked to omega-3 fatty acid levels.
Discover your omega-3 levels based on your DNA through our Health TenDNA report.
Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Omega-3, unsaturated fatty acids and see a list of existing studies.
SNP polymorphisms related to the topic Omega-3, unsaturated fatty acids:
| rs174546 | Variations in the FADS1 gene interact with and are associated with changes in fatty acid composition in cortical tissue. |
| rs174575 | Variants in the FADS gene modify the relationship between fish consumption and docosahexaenoic acid content in breast milk. This in turn affects the child's cognitive function and hyperactivity/attention problems. |
| rs174448 | The gene polymorphism alters EPA and DHA levels and their effects in brain development and function. |
| rs174550 | The fatty acid desaturase (FADS) gene polymorphism is associated with insulin resistance, type 2 diabetes and impaired fasting glucose levels in adults. |
| rs3834458 | Single nucleotide polymorphism rs3834458 affects levels of n-3 long-chain polyunsaturated fatty acids. |
| rs174548 | Polymorphisms in this gene are associated with decreased levels of omega-3 fatty acids, increased relative levels of omega-6 fatty acids and increased concentrations of trans-unsaturated fatty acids. In vegetarians, some polymorphisms of this gene may result in an undesirable situation associated with increased inflammation. |
| rs174537 | Polymorphisms in the fatty acid desaturase (FADS) gene cluster modify the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles. |
| rs174553 | Polymorphisms in the fatty acid desaturase (FADS) gene cluster can modify the effects of fish oil supplementation on the fatty acid profile of blood and erythrocytes. |
| rs174547 | Genetic variants that affect circulating lipid levels and risk of cardiovascular disease. People with the C gene variant have lower levels of long forms of fatty acids such as AA. Vegetarians and vegans with the C gene variant have lower plasma concentrations of EPA, DHA and AA than omnivores. Vegetarians with the C gene variant have been shown to benefit from omega-3 supplements or omega-3 rich foods such as chia seeds, flax seeds and canola oil. |
| rs174570 | Genetic polymorphisms of FADS are associated with fatty acid metabolism through changes in DNA methylation and gene expression. |
| rs174583 | Fatty acid desaturase gene polymorphism increases insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition. |
| rs498793 | Fatty acid desaturase gene breakage increases the manifestations of attention-deficit/hyperactivity disorder. |
| rs1535 | FADS2 polymorphisms affect blood levels of omega-3 and omega-6 polyunsaturated fatty acids during pregnancy, at birth, and at age 7 years. |
| rs174556 | FADS gene polymorphisms increase arachidonic acid levels and risk of Alzheimer's disease. |
| rs174561 | FADS gene polymorphism alters serum glycerophospholipid fatty acid concentrations and their percentage composition in children. |
| rs953413 | ELOVL2 gene polymorphisms are associated with increased proportions of eicosapentaenoic and docosahexaenoic acids in plasma after fish oil intake. |
| rs174602 | Determines the effect of omega-3 fatty acids on the biomarker activity of metals and persistent organic pollutants. |
| rs2277324 | Affects changes in blood levels of polyunsaturated fatty acids. |
| rs7744440 | Affects changes in blood levels of polyunsaturated fatty acids. |
| rs16940765 | Affects changes in blood levels of polyunsaturated fatty acids. |
| rs17718324 | Affects changes in blood levels of polyunsaturated fatty acids. |
| rs99780 | |
| rs174576 | |
| rs174577 | |
| rs174579 | |
| rs174593 | |
| rs174618 | |
| rs1570069 | |
| rs2072114 | |
| rs2727270 | |
| rs3798719 | |
About The Author
Li Dali
Li Dali, a National Foundation for Outstanding Youth Fund recipient, is a researcher at the School of Life Sciences in East China Normal University. He earned his PhD in genetics from Hunan Normal University in 2007 and conducted collaborative research at Texas A&M University during his doctoral studies. Li Dali and his team have optimized and innovated gene editing technology, leading to the establishment of a world-class system for constructing gene editing disease models. A condition affecting the oxidation of long-chain fatty acids, Carnitine palmitoyltransferase II... The activated ligand-regulated transcription factors collectively known as nuclear receptors... The CYP21A2 gene encodes the human protein, Steroid 21-hydroxylase. This enzyme hydroxylates...
