SNP information rs174537

Research and publications:

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19148276   Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.

  19798445   Genetic determinants of circulating sphingolipid concentrations in European populations.

  19996744   Fatty acid interactions with genetic polymorphisms for cardiovascular disease.

  20562440   FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

  20565855   Genetic variation in lipid desaturases and its impact on the development of human disease.

  21040914   FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.

  21115529   Genetics and genomics of human ageing.

  21383846   Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.

  21421807   Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

  21513558   Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.

  21599946   The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

  21733300   Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

  22073310   Association of genetic loci with blood lipids in the Chinese population.

  22194195   Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.

  22563332   Fatty Acid desaturase gene variants, cardiovascular risk factors, and myocardial infarction in the costa rica study.

  23028684   Adaptive evolution of the FADS gene cluster within Africa.

  23160180   Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.

  23285256   Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.

  24842322   DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.

  24853887   Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.

  24936800   The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements.

  24962583   Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.

  26474818   Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.

  26885902   [Association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis].

  26891335   Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.

  26950146   Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes.

  27004414   Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.

  27005424   Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.

  27146020   Colorectal cancer risk genes are functionally enriched in regulatory pathways.

  27197070   Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer.

  28084440   Common risk variants for colorectal cancer: an evaluation of associations with age at cancer onset.

  28333262   Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes.

  28552045   Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians.

  28577571   Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.

  28598979   Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.

  28929400   Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study.

  28957329   Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.

  29080057   Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes.

  29258461   Effects of interactions between common genetic variants and smoking on colorectal cancer.

  29545352   Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.

  29636834   Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes.

  30050886   Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population.

  30082751   FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.

  30588120   Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study.

  32167131   Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.

  32253986   A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury.

  32433731   Maternal Long-Chain Polyunsaturated Fatty Acid Status, Methylmercury Exposure, and Birth Outcomes in a High-Fish-Eating Mother-Child Cohort.

  33024925   Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial.

  33073494   An in silico approach to identify and prioritize miRNAs target sites polymorphisms in colorectal cancer and obesity.

  33310680   Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.

  33526157   Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.

  33595419   Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.

  34189740   FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.

  35182678   Single nucleotide polymorphism of fatty acid desaturase gene and breast cancer risk in estrogen receptor subtype.

  35871074   Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study.