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SNP information rs174548

RS174548

Normal allele: CC

Polymorphisms in this gene are associated with decreased levels of omega-3 fatty acids, increased relative levels of omega-6 fatty acids and increased concentrations of trans-unsaturated fatty acids. In vegetarians, some polymorphisms of this gene may result in an undesirable situation associated with increased inflammation.

Polymorphism rs174548 is related to topics like this:

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Research and publications:

  19043545   Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

  20081858   New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  20864672   Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

  21421807   Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

  21829377   Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

  22546284   Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations.

  22606979   Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New World.

  22900039   Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue.

  22960237   Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.

  23028684   Adaptive evolution of the FADS gene cluster within Africa.

  23101478   Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

  24665059   Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population.

  24853887   Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.

  25626431   Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.

  25646338   Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

  27355821   Characterizing Blood Metabolomics Profiles Associated with Self-Reported Food Intakes in Female Twins.

  28259851   Study protocol to investigate the environmental and genetic aetiology of atopic dermatitis: the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI).

  28555039   FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.

  28598979   Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.

  28929400   Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study.

  28968813   Metabolome-wide association study identified the association between a circulating polyunsaturated fatty acids variant rs174548 and lung cancer.

  29847832   Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.

  33031748   A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.

  33177615   Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population.

  34980917   Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.

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