Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Vitamin B4 (choline) and see a list of existing studies.
SNP polymorphisms related to the topic Vitamin B4 (choline):
|Genetic polymorphisms in methyl group metabolism DNA methylation in peripheral blood. Affect the human need for choline (vitamin B4).
|Polymorphisms in this gene are associated with decreased levels of omega-3 fatty acids, increased relative levels of omega-6 fatty acids and increased concentrations of trans-unsaturated fatty acids. In vegetarians, some polymorphisms of this gene may result in an undesirable situation associated with increased inflammation.
|The protein encoded by the gene transports folic acid into the cell and thus plays a role in the intracellular regulation of folate concentration. In this genotype, folate absorption is worse. Folic acid requirement is higher. Alcohol consumption is more critical for the risk of vitamin B9 deficiency.
|Genetic variability in the choline-O-acetyltransferase gene influences increased risk of depression and Alzheimer's disease.
|Possible increased risk of fetal birth defects. A 1.5-fold higher risk for Caucasian mothers to give birth to children with DNT (neural tube defect). The association in children with this mutation with an increased risk of heart defects is greater if their mother did not get enough folic acid during pregnancy. The risk is reduced with adequate levels of folic acid and vitamin B6.
|Choline pathway gene polymorphism increases the risk of intrauterine foetal death.