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SNP information rs7946


Normal allele: CC

Genetic polymorphisms in methyl group metabolism DNA methylation in peripheral blood. Affect the human need for choline (vitamin B4).

Polymorphism rs7946 is related to topics like this:

DNA methylation genes

The Genetic Methylation Check examines your DNA to offer insights into your unique methylation...

Choline mthfr

Choline (vitaman B4) is a vital nutrient often lacking in many diets. Indeed, a large portion of...

Mitochondria dna

The mitochondria contain circular chromosomes known as mitochondrial DNA and are organelles...

Vegetarian genetic

Various reasons drive individuals to experiment with a vegetarian diet, ranging from ethical and...

Research and publications:

  16816108   Common genetic polymorphisms affect the human requirement for the nutrient choline.

  17613168   Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.

  18230680   Choline metabolism and risk of breast cancer in a population-based study.

  18789905   Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models.

  19167960   Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.

  21204206   Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population

  21857689   Folate and vitamin B12 in idiopathic male infertility.

  21881829   PEMT G523A (V175M) is associated with sporadic Alzheimer's disease in the Chinese population.

  22116453   Folate and vitamin B12-related genes and risk for omphalocele.

  22371529   DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study.

  22856873   Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects.

  23446900   One-carbon metabolism factors and leukocyte telomere length.

  25240073   Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.

  26636496   Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of nonalcoholic fatty liver disease: evidence from meta-analysis.

  27488260   Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China.

  27610012   Metabolic aspects of adult patients with nonalcoholic fatty liver disease.

  28134761   Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.

  28596988   NAFLD Susceptibility Genes and their Association with Type 2 Diabetes and Obesity in a New Mexico Population.

  31199045   Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.

  31695245   Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease.

  33503637   Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study.

  34233321   Comparison of Associations between One-Carbon Metabolism, Lipid Metabolism, and Fatty Liver Markers in Normal-Weight and Overweight People Aged 20-40 Years.

  35668704   Associations of plasma betaine, plasma choline, choline intake, and MTHFR polymorphism (rs1801133) with anthropometric parameters of healthy adults are sex-dependent.

  36012560   Hepatic PEMT Expression Decreases with Increasing NAFLD Severity.

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