Normal allele: CC
Genetic polymorphisms in methyl group metabolism DNA methylation in peripheral blood. Affect the human need for choline (vitamin B4).
Polymorphism rs7946 is related to topics like this:
Research and publications:
16816108 Common genetic polymorphisms affect the human requirement for the nutrient choline.
18230680 Choline metabolism and risk of breast cancer in a population-based study.
21857689 Folate and vitamin B12 in idiopathic male infertility.
21881829 PEMT G523A (V175M) is associated with sporadic Alzheimer's disease in the Chinese population.
22116453 Folate and vitamin B12-related genes and risk for omphalocele.
22856873 Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects.
23446900 One-carbon metabolism factors and leukocyte telomere length.
27610012 Metabolic aspects of adult patients with nonalcoholic fatty liver disease.
36012560 Hepatic PEMT Expression Decreases with Increasing NAFLD Severity.