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Methylation and homocysteine DNA health report

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Methylation and homocysteine and see a list of existing studies.

SNP polymorphisms related to the topic Methylation and homocysteine:

rs4633Catechol-O-methyltransferase deficiency is associated with total plasma homocysteine levels and may increase the risk of venous thrombosis.
rs4680The study showed a 10% increase in total plasma homocysteine (tHcy)
rs7946Genetic polymorphisms in methyl group metabolism DNA methylation in peripheral blood. Affect the human need for choline (vitamin B4).
rs10380Breakage causes deficiency of vitamin B12 - methylcobalamin cblE and impaired methylation. Supplementation with increased doses of vitamin B12 in the active form is required. The polymorphism is also associated with the risk of pancreatic cancer.
rs162036Disorders of intracellular metabolism of cobalamin. Positive effect on the efficacy of folic acid therapy in patients with hyperhomocysteinaemia.
rs234706A cystathionine beta-synthase polymorphism that increases the risk of hyperhomocysteinaemia.
rs502396
rs526934Causes decreased concentrations of vitamin B6, vitamin B12, folic acid and increased homocysteine in the blood.
rs567754The detected C/T genotype contains a risky "T" allele, which potentially reduces the efficiency of the methylation process and may impair health outcomes.
rs651852The detected genotype contains a risk allele, which potentially reduces the efficiency of the methylation process and may impair health. The activity of this gene may be reduced by psychological stress, which increases cortisol levels
rs651933May mean that folic acid cannot be transported into cells, and may indicate a need for more folic acid
rs819171The risk allele reduces the activity of the AHCY gene, which can decrease the formation of S-adenosylmethionine (SAM-e), and in turn increase the accumulation of homocysteine and ammonia in the body. SAM-e deficiency has been linked to a variety of health disorders including depression, mood swings, arthritis and fibromyalgia.
rs1051266The protein encoded by the gene transports folic acid into the cell and thus plays a role in the intracellular regulation of folate concentration. In this genotype, folate absorption is worse. Folic acid requirement is higher. Alcohol consumption is more critical for the risk of vitamin B9 deficiency.
rs1076991
rs1131603Changes in transcobalamin2 concentration associated with post-stroke homocysteine alter the risk of recurrent stroke.
rs1476413
rs1799983Decreases the activity of the NOS3 gene and may reduce the efficiency of the methylation process. Also associated with increased risk markers for cardiovascular problems, such as total cholesterol and low-density lipoprotein (LDL) levels, and with an increased risk of high blood pressure, especially in pregnant women.
rs1800779Gene polymorphisms are associated with cardiovascular disease risk markers, impaired methylation.
rs1801131Reduces the formation of the active form of folic acid, which is necessary for the remethylation of homocysteine and other DNA molecules. Administration of the active form of folic acid (5-MTHF or L-methyltetrahydrofolate) can significantly improve risk scores for the effects of mutations. Also a factor that moderately increases the need for vitamin B2.
rs1801133A gene fragment known as MTHFR C677T, which encodes an enzyme involved in folic acid metabolism. A break in this gene fragment results in high levels of homocysteine, low levels of B12 and folic acid. If your tests show high homocysteine levels, your doctor will likely advise you on an appropriate diet and supplementation regime. Taking varieties of the active form of B9 methylfolate (5-MTHF or L-methyltetrahydrofolate), the active form of vitamin B12, methylcobalamin, is recommended to reduce your risks.
rs1801394Polymorphism can lead to elevated homocysteine levels independent of folic acid, vitamin B12 or B6 levels. It is a risk factor for neural tube defects and Down syndrome in the setting of higher homocysteine levels.
rs1802059
rs1805087Moderate risk factor for hyperhomocysteinaemia. A factor that increases the body's need for folic acid and vitamin B12.
rs1979277Polymorphism of enzymes that metabolise folic acid.It is required to obtain sufficient vitamin B6 for optimal gene activity.
rs1999594Causes decreased concentrations of vitamin B6, vitamin B12, folic acid and increased homocysteine in the blood.
rs2236225Possible increased risk of fetal birth defects. A 1.5-fold higher risk for Caucasian mothers to give birth to children with DNT (neural tube defect). The association in children with this mutation with an increased risk of heart defects is greater if their mother did not get enough folic acid during pregnancy. The risk is reduced with adequate levels of folic acid and vitamin B6.
rs2274976The polymorphism is associated with an increase in plasma homocysteine dependent on vitamin B12 and folate B9.
rs2283873
rs2287780Polymorphism in folic acid pathway genes causing B12 deficiency and increased homocysteine.
rs3733890BHMT gene polymorphism leads to increased BHMT gene activity (also known as "upregulation"). Up-regulation of BHMT may lead to lower homocysteine levels, and less dependence on folic acid and vitamin B-12 as methyl donors.
rs3741049The gene defect causes 3-ketothiolase deficiency, which causes the growth of intestinal microbes (especially clostridia) and negatively affects methylation.
rs4244593
rs4654748Breakage causes a deficiency of the active form of vitamin B6, pyridoxal-5'-phosphate (p-5-p). Supplemental intake of p-5-p is recommended.
rs4820889Changes in transcobalamin2 concentration associated with post-stroke homocysteine alter the risk of recurrent stroke.
rs6495446
rs9606756Polymorphism associated with serum levels of vitamin B12. Also associated with transcobalamin concentrations in pregnant women and risk of neural tube defects in the foetus.
rs11754661Genetic alteration of the folate pathway affecting genomic methylation content.
rs17349743Gene responsible for folate pathway abnormalities, increases likelihood of late-onset Alzheimer's disease.
rs17367504The polymorphism is associated with increased plasma homocysteine and increased risk of hypertension.
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