SNP information rs3733890

Research and publications:

  16816108   Common genetic polymorphisms affect the human requirement for the nutrient choline.

  17035141   Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions

  17613168   Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.

  18203168   Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts

  18230680   Choline metabolism and risk of breast cancer in a population-based study.

  18457970   Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.

  18521744   BRCA1 promoter methylation is associated with increased mortality among women with breast cancer

  18708404   B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer

  18789905   Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models.

  19048631   Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study

  19261726   Epigenetic mechanisms for nutrition determinants of later health outcomes.

  19376481   One-carbon metabolism and breast cancer: an epidemiological perspective

  19493349   118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

  19635752   High intakes of choline and betaine reduce breast cancer mortality in a population-based study.

  19683694   Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida

  19737740   Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.

  19936946   Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer

  20111745   Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects

  20436254   Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements.

  20664391   Maternal folate-related gene environment interactions and congenital heart defects.

  21093336   Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.

  21146954   Genes and abdominal aortic aneurysm

  21204206   Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population

  21254358   Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.

  21254359   Folate pathway and nonsyndromic cleft lip and palate.

  21281325   Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis.

  21349258   Folate and choline metabolism gene variants and development of uterine cervical carcinoma.

  21429654   Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21474952   Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements.

  21610500   Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism.

  21615938   Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder.

  21688148   Polymorphic variants of genes involved in homocysteine metabolism in celiac disease.

  21857689   Folate and vitamin B12 in idiopathic male infertility.

  21881118   Genetic variants and susceptibility to neurological complications following West Nile virus infection.

  22116453   Folate and vitamin B12-related genes and risk for omphalocele.

  22183302   Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population.

  22371529   DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study.

  22496743   Genetic variant of AMD1 is associated with obesity in urban Indian children.

  22616673   Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.

  22792358   Association between genetic variants in DNA and histone methylation and telomere length.

  22833659   Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults.

  23294634   Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.

  23446900   One-carbon metabolism factors and leukocyte telomere length.

  23656756   Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults.

  24048206   Neural tube defects, folic acid and methylation.

  24130171   Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.

  24524080   The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.

  25303517   Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy.

  26451011   Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.

  27452984   PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.

  27488260   Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China.

  27677362   Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.

  28134761   Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.

  28582843   Acute lymphoblastic leukemia and genetic variations in BHMT gene: Case-control study and computational characterization.

  28770393   Association of neural tube defects with gene polymorphisms in one-carbon metabolic pathway.

  29407547   Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems.

  31111486   Association between the BHMT gene rs3733890 polymorphism and the efficacy of oral folate therapy in patients with hyperhomocysteinemia.

  31451344   Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis.

  31826386   Genetic and epigenetic regulation of BHMT is associated with folate therapy efficacy in hyperhomocysteinaemia.

  33195260   Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors.

  33714108   Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis.

  35001080   Using the optimal method-explained variance weighted genetic risk score to predict the efficacy of folic acid therapy to hyperhomocysteinemia.