Normal allele: TT
The risk allele reduces the activity of the AHCY gene, which can decrease the formation of S-adenosylmethionine (SAM-e), and in turn increase the accumulation of homocysteine and ammonia in the body. SAM-e deficiency has been linked to a variety of health disorders including depression, mood swings, arthritis and fibromyalgia.
Polymorphism rs819171 is related to topics like this: