Upload the DNA data file of the test

23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage

and get an enhanced
personalized health report
free without registration

Files accepted .txt, .csv, .zip, .csv.gz

File data is not stored on the server

SNP information rs1799983

Normal allele: GG

Decreases the activity of the NOS3 gene and may reduce the efficiency of the methylation process. Also associated with increased risk markers for cardiovascular problems, such as total cholesterol and low-density lipoprotein (LDL) levels, and with an increased risk of high blood pressure, especially in pregnant women.

Polymorphism rs1799983 is related to topics like this:

Methylation and homocysteine
Ischemic heart disease
Infertility and miscarriage

Research and publications:

  9737779   A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.

  9894802   Coronary artery disease is not associated with the E298-->D variant of the constitutive, endothelial nitric oxide synthase gene.

  10475066   The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease.

  10510054   A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.

  11354626   The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption.

  11394896   Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy.

  11745998   Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy.

  15007011   Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects.

  15500681   Detecting imbalanced expression of SNP alleles by minisequencing on microarrays.

  15726497   Gene-environment interaction effects on the development of immune responses in the 1st year of life

  16059745   The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia.

  16813604   Genetic association between endothelial nitric oxide synthase and Alzheimer disease.

  16820586   Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery

  17101543   Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy.

  17107626   Comparison of PrASE and Pyrosequencing for SNP Genotyping

  17165044   The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies.

  17404185   Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study.

  17579350   NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits.

  17601350   A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

  17605790   Lack of association between endothelial nitric oxide synthase (NOS3) gene polymorphisms and suicide attempts.

  17717598   Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

  17980690   Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans.

  18069999   Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study.

  18194558   A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.

  18246059   Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.

  18279468   Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure.

  18349107   Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis.

  18482449   Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites.

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18622260   Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke.

  18676870   Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China

  18682580   Oxidative response gene polymorphisms and risk of adult brain tumors.

  18687083   Lack of association of endothelial nitric oxide synthase polymorphisms and migraine.

  18698212   Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18776599   Susceptibility genes for gentamicin-induced vestibular dysfunction.

  18805939   Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19132956   A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension.

  19168583   Nitric oxide synthase gene polymorphisms and prostate cancer risk.

  19246226   The endothelial nitric oxide synthase gene and risk of diabetic nephropathy and development of cardiovascular disease in type 1 diabetes.

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19419976   Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage.

  19423521   Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma.

  19435423   Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population.

  19505917   Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19587357   A systematic meta-analysis of genetic association studies for diabetic retinopathy

  19661472   Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study.

  19726494   Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency.

  19729601   Candidate gene polymorphisms for ischemic stroke.

  19773451   Role of inflammation gene polymorphisms on pain severity in lung cancer patients

  19815736   Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use.

  19884647   Air pollution, obesity, genes and cellular adhesion molecules

  19960019   Association of NOS3 Glu298Asp SNP with hypertension and possible effect modification of dietary fat intake in the ARIC study.

  20124951   Vascular endothelial growth factor pathway.

  20204503   The association between two polymorphisms of eNOS and breast cancer risk: a meta-analysis.

  20346360   Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.

  20367485   A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population.

  20406163   Fenofibrate and metabolic syndrome.

  20406466   Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

  20409549   NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids.

  20417488   Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

  20445800   Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.

  20457799   Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia.

  20521218   Progress toward genetic tailoring of heart failure therapy.

  20565774   Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

  20577119   Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.

  20581851   Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD.

  20624112   Tamm-Horsfall protein gene is associated with distal tubular dysfunction in patients with type 1 diabetes.

  20691505   NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.

  20711808   Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

  20810793   Endothelial nitric oxide synthase gene variation associated with chronic kidney disease after liver transplant.

  20811626   Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer

  20941391   Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study

  20952631   Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study.

  21048526   Doxorubicin pathways: pharmacodynamics and adverse effects.

  21054877   Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

  21056700   Lack of replication in polymorphisms reported to be associated with atrial fibrillation.

  21058046   Genetics of salt-sensitive hypertension.

  21174581   Genetic variants, endothelial function, and risk of preeclampsia among American Indians.

  21252862   NOS3 variants, physical activity, and blood pressure in the European Youth Heart Study.

  21291465   The association of genetic polymorphisms with cerebral palsy: a meta-analysis.

  21293869   Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk.

  21332392   Endothelial nitric oxide synthase haplotypes associated with aura in patients with migraine.

  21437030   Genetics and cardiovascular system: influence of human genetic variants on vascular function.

  21533139   Predicting diabetic nephropathy using a multifactorial genetic model.

  21537392   Endothelin-1 and endothelial nitric oxide polymorphisms in idiopathic pulmonary arterial hypertension.

  21577011   NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls.

  21613201   The effect of maternal and fetal β2-adrenoceptor and nitric oxide synthase genotype on vasopressor requirement and fetal acid-base status during spinal anesthesia for cesarean delivery.

  21670344   Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking.

  21674837   Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy.

  21703358   Polymorphisms in nitric-oxide synthase 3 may influence the risk of urinary-bladder cancer.

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21886581   Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese.