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Heart disease genetic

If you tested your DNA with a personal genomics service like 23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage or another testing company, you can learn more about your risk factors for hundreds of diseases. By clicking the button above ⬆️, you can upload your raw DNA data file and receive a personalized 250-page health report with research links that is the most comprehensive.

Although genetics can be a major factor in the development of certain heart diseases, individuals with inherited risk factors can decrease their likelihood of developing heart disease by adopting healthy lifestyle habits.

Heart disease encompasses various conditions that can impact an individual's heart or blood vessels, potentially leading to chest pain, stroke, or a heart attack. The likelihood of developing specific heart conditions can be influenced by one's genetics, inherited from their parents.

Inherited conditions arise from a defect or alteration in one or multiple genes. The likelihood of inheriting a defective gene increases if one of your parents possesses it. A few prevalent inherited conditions include:

Diseases of the heart muscle

Heart rhythms that pose a risk to life.

Cholesterol levels are extremely elevated.

Cardiomyopathies can be caused by various gene variations. Specifically, the development of cardiomyopathies has been associated with the following genes:

MYBPC3 can be rewritten as Myosin Binding Protein C, Cardiac.

Trusted Source: TNNT2

TNNI3 from a reliable source.

Familial hypercholesterolemia (FH) is among the associated conditions caused by other genes that may heighten the likelihood of heart disease.

PCSK9 can be rewritten as proprotein convertase subtilisin/kexin type 9.

The likelihood of developing specific heart diseases may be influenced by an individual's genetics. In the event that an individual's family has a history of heart disease, it is advisable to seek medical advice regarding screening alternatives. These may involve gathering data from family members and undergoing genetic testing.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Ischemic heart disease and see a list of existing studies.

SNP polymorphisms related to the topic Ischemic heart disease:

rs4665058There is an approximately 4-fold increased risk of sudden cardiac death, presumably from myocardial infarction.
rs599839The rs599839 polymorphism on chromosome 1p13.3 is associated with premature coronary heart disease.
rs556621The rs556621 variant on chromosome 6p21.1 is associated with large artery atherosclerotic stroke and ischaemic stroke.
rs46522The rs46522 polymorphism of the E2Z ubiquitin-conjugating enzyme gene is associated with abnormal metabolic parameters in patients with myocardial infarction.
rs10455872The rs10455872(G) allele of the LPA gene is associated with high levels of lipoprotein and elevated calcium in the aortic valve, coronary artery disease and coronary heart disease.
rs17465637SNP of the MIA3 gene associated with increased risk of myocardial infarction with odds ratios of 1.17 (CI: 1.04-1.32) and 1.37 (CI: 1.08-1.74) for carriers.
rs3798220rs3798220, also known as I4399M or Ile4399Met, is a SNP in the apolipoprotein (A) LPA gene , which has been reported to be associated with elevated plasma lipoprotein levels and increased cardiovascular risk, well-tolerated by low-dose aspirin.
rs12425791NINJ2 promoter polymorphism causes association with ischaemic stroke.
rs383830Male-specific association of the T allele of APC rs383830 with risk of coronary heart disease.
rs1676232LSAMP tumour suppressor gene polymorphisms define a significant risk haplotype for left main artery coronary heart disease.
rs964184Involved in lipid and vitamin E metabolism. The genotype is a moderate risk factor for reduced vitamin E levels. A low-fat diet is suitable for people with this defect. On a low-fat diet (20% of energy comes from fat), carriers of the risk allele (allele G) had greater reductions in OX and LDL cholesterol levels. These studies showed better lipid profile improvement with long-term low-fat dietary intake in the risk allele G.
rs1333042Intronic polymorphisms in the CDKN2B-AS1 gene are strongly associated with the risk of myocardial infarction and coronary heart disease.
rs2505083Increased risk of sudden myocardial infarction and coronary heart disease.
rs1024611Increased risk of exercise-induced ischaemia. Also increased rate of HIV progression.
rs2895811HHIPL-1 gene polymorphism (rs2895811) is associated with cardiovascular risk factors and cardiometabolic parameters in patients with myocardial infarction.
rs11984041HDAC9 variant associated with large vessel ischaemic stroke contributes to carotid atherosclerosis.
rs2107595HDAC9 Rs2107595 variant alters susceptibility to coronary heart disease and severity of coronary atherosclerosis.
rs879324Genetic risk factor for ischaemic and haemorrhagic stroke.
rs6843082Genetic risk factor for ischaemic and haemorrhagic stroke.
rs1799983Decreases the activity of the NOS3 gene and may reduce the efficiency of the methylation process. Also associated with increased risk markers for cardiovascular problems, such as total cholesterol and low-density lipoprotein (LDL) levels, and with an increased risk of high blood pressure, especially in pregnant women.
rs662799Apolipoprotein A5 polymorphisms increase 1.4-fold the risk of early heart attack.
rs1333048ANRIL genetic variation is strongly associated with the risk of myocardial infarction and coronary heart disease.
rs3135506A variant of the apolipoprotein A5 gene affects lipids, lipoproteins and is associated with coronary heart disease.
rs3782218A single nucleotide polymorphism of nitric oxide synthase (NOS) is associated with coronary heart disease.
rs1412444A single nucleotide polymorphism in the LIPA (lysosomal acidic lipase A) gene is associated with predisposition to premature coronary heart disease.
rs646776A new locus of coronary atherosclerosis and associations with myocardial infarction in coronary atherosclerosis.
rs671A mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene increases acute alcohol sensitivity, alcohol dependence and hangover susceptibility.
rs10757274A genetic variant on chromosome 9p21 is the strongest genetic predictor of early myocardial infarction (heart attack) found so far. SNPs in this region are also associated with an increased risk of stroke, abdominal aortic aneurysm (AAA) and intracranial aneurysm.
rs1842896
rs12740374
rs12413409
rs11671653
rs2259816
rs7203193
rs6504218
rs11669133
rs12200560
rs9546711
rs1994016
rs3729639
rs3127599
rs7767084
rs1746048
rs9818870
rs12526453
rs6601299
rs7569328
rs974819
rs11650066
rs9268402
rs4773144
rs1231206
rs12936587
rs7697839
rs2515629
rs514659
rs10933436
rs17114046
rs6905288
rs1333040
rs10757278
rs2383207
rs7025486
rs4977574
rs1333049
rs2383206
rs11206510
rs9349379
rs16851055
rs13407662
rs2306374
rs7586970
rs11066015
rs8055236
rs10755578
rs675026
rs7136259
rs10953541
rs8060686
rs11752643
rs2123536
rs4743150
rs9982601
rs12190287
rs11556924
rs1165669
rs2472299
rs3869109
rs17114036
rs1263173
rs2346177
rs708272
rs6882776
rs28936670
rs72554028
rs703752
rs1063192
rs2811712
rs2857657
rs10116277
rs5443
rs6922269
rs501120
rs20455
rs7250581
rs688034
rs2943634
rs17228212
rs2713604
rs3803
rs1800787
rs4404477
rs2331291
rs3918242
rs2238151
rs579459
rs886126
rs17672135
rs11066280
rs6725887
rs7808424
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