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SNP information rs671

Normal allele: GG

A mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene increases acute alcohol sensitivity, alcohol dependence and hangover susceptibility.

Polymorphism rs671 is related to topics like this:

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Research and publications:

  2987944   Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

  4065146   Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.

  6582480   Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.

  7180842   Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity.

  7593603   The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells.

  8903321   The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion.

  10627091   Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene.

  10780266   Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.

  15654505   Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples.

  16046871   Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers.

  16440063   Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.

  16595073   Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations

  17885622   Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.

  18056758   Major genetic components underlying alcoholism in Korean population.

  18317873   Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs).

  18331377   Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.

  18996923   Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.

  19041386   Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

  19262484   Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.

  19430479   Genome-wide association study of blood pressure and hypertension.

  19641380   Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans.

  19698717   Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

  19706845   A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population.

  19826048   Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran

  20010786   Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.

  20093384   Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population.

  20100738   Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.

  20417517   The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.

  20505153   A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

  20518787   Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.

  20585100   Genome-wide association studies of cancer.

  20616999   Usefulness of Mendelian randomization in observational epidemiology.

  20729852   A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

  20833657   Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.

  20981351   Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.

  21083667   Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.

  21315679   Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population

  21338875   Genetic vulnerability and susceptibility to substance dependence

  21351086   Shortened telomeres in individuals with abuse in alcohol consumption.

  21367945   Genome-wide association studies of alcohol intake--a promising cocktail?

  21372407   Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.

  21437268   A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

  21455501   Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21572416   Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

  21576033   ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.

  21900886   Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study.

  21917409   Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers.

  21926110   Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.

  21946912   Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese.

  21971053   Genome-wide association study of coronary artery disease in the Japanese.

  22004425   Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study.

  22004471   Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.

  22010049   Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.

  22102315   Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.

  22171074   A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.

  22301922   Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges.

  22507220   Epidemiologic differences in esophageal cancer between Asian and Western populations.

  22508505   Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.

  22551939   Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population.

  22560290   A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.

  22640768   The genetic basis of addictive disorders.

  22674868   Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China.

  22675424   ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies.

  22806211   The genetics of addiction-a translational perspective.

  22839215   Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption.

  22865593   Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.

  22930414   Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China.

  23072573   Multiplex allele-specific amplification from whole blood for detecting multiple polymorphisms simultaneously.

  23088731   Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis.

  23243119   Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men?

  23364009   Common variants at 12q24 are associated with drinking behavior in Han Chinese.

  23430454   Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population.

  23455379   The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.

  23629646   Epidemiology of esophageal cancer in Japan and China.

  23685282   Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis.

  23697560   ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression.

  23969552   Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes.

  24037726   Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.

  24274136   Biobanking across the phenome - at the center of chronic disease research.

  24277619   ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.

  24633362   ALDH2 and ADH1 genetic polymorphisms may contribute to the risk of gastric cancer: a meta-analysis.

  24652602   Alcohol consumption and lifetime change in cognitive ability: a gene × environment interaction study.

  24861553   Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

  24968322   Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population.

  25045619   The Genetics, Neurogenetics and Pharmacogenetics of Addiction.

  25047496   Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients.

  25133033   Epidemiological studies of esophageal cancer in the era of genome-wide association studies.

  25313998   The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels.

  25403981   Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations.

  25411394   Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees.

  25427900   Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.

  25543168   Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees.

  25573768   Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan.

  25636114   [Advance in research on the association of ALDH2 gene polymorphisms with cancer susceptibility in drinkers].

  25680115   Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis.

  25803854   Genotyping on ALDH2: comparison of four different technologies.

  26125444   Family history of cancer and the risk of squamous cell carcinoma of oesophagus: a case-control study in Kashmir, India.

  26174136   Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.

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