SNP information rs646776

Research and publications:

  18179892   Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

  18193044   Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

  18262040   LDL-cholesterol concentrations: a genome-wide association study.

  18852197   Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

  19060906   Common variants at 30 loci contribute to polygenic dyslipidemia.

  19060910   Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

  19060911   Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

  19198609   Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

  19299407   Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample

  19380133   Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosis.

  19435741   Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.

  19679263   Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.

  19729614   Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.

  19802338   Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicatio

  19919681   Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  19955471   Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study.

  19956433   Genetics of coronary artery disease: focus on genome-wide association studies.

  20031591   Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.

  20084173   Magnitude of stratification in human populations and impacts on genome wide association studies.

  20339536   Genome-wide association of lipid-lowering response to statins in combined study populations.

  20502693   Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

  20570915   Genetic determinants of major blood lipids in Pakistanis compared with Europeans.

  20570916   Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.

  20686566   From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

  20729558   Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies.

  20832063   Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

  20835900   Genetics of diabetes complications.

  20971364   A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.

  21087763   Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

  21178099   SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy.

  21239051   Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.

  21242481   Genetic risk score and risk of myocardial infarction in Hispanics.

  21297524   The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.

  21369780   Genome-wide association studies in atherosclerosis.

  21466885   Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.

  21606135   A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

  21626010   Human genetics as a tool to identify progranulin regulators.

  21637794   Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.

  21738485   Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  21862702   Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

  21867541   Evaluation of the global association between cholesterol-related polymorphisms and Alzheimer's disease suggests a role for rs3846662 splicing and HMGCR in disease risk.

  21875899   Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour.

  21966275   Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

  22003152   Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.

  22144573   Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

  22152955   Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.

  22216278   Large scale association analysis identifies three susceptibility loci for coronary artery disease.

  22363065   Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?

  22425169   Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.

  22429504   Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece.

  22654721   Recent insights into the involvement of progranulin in frontotemporal dementia.

  22848412   Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts.

  22882272   Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke.

  23067240   Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels.

  23092954   SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits

  23098650   Impact of variants within seven candidate genes on statin treatment efficacy.

  23100282   Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

  23398167   Decreased serum progranulin levels may be associated with the risk of Parkinson's disease.

  23468967   Improvement in prediction of coronary heart disease risk over conventional risk factors using SNPs identified in genome-wide association studies.

  23755065   Mapping Novel Pathways in Cardiovascular Disease Using eQTL Data: The Past, Present, and Future of Gene Expression Analysis.

  23964269   The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.

  24270849   Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data.

  24373676   Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.

  24725463   Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study.

  24728607   Genetic variants in loci 1p13 and 9p21 and fatal coronary heart disease in a Norwegian case-cohort study.

  24771538   Progranulin protein levels are differently regulated in plasma and CSF.

  24931982   GRASP: analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database.

  24991929   Association of common genetic variants with lipid traits in the Indian population.

  25042869   SORT1 protective allele is associated with attenuated postprandial: lipaemia in young adults.

  25182463   Metabolomics reveals the sex-specific effects of the SORT1 low-density lipoprotein cholesterol locus in healthy young adults.

  26252781   Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11.

  26345841   Association between 1p13.3 genomic markers and coronary artery disease: a meta-analysis involving patients and controls.

  26686871   Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies.

  26719772   Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome.

  26780889   Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

  26839654   Genetics of coronary artery disease and myocardial infarction.

  26847647   Experimental Biology for the Identification of Causal Pathways in Atherosclerosis.

  26849123   An Adaptive Ridge Procedure for L0 Regularization.

  26892960   From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease.

  26958643   Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.

  27042264   Genetics of cardiovascular and renal complications in diabetes.

  27112212   Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.

  27286809   Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

  27294088   Genetics of the acute coronary syndrome.

  27329260   Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.

  27392867   A genetic variant of the sortilin 1 gene is associated with a reduced risk of Alzheimer's disease.

  27612602   Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.

  27703466   Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers.

  27716211   A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.

  27943270   A genetic risk score is significantly associated with statin therapy response in the elderly population.

  28088267   A meta-analysis of three identified single nucleotide polymorphisms at 1p13.3 and 1q41 and their associations with lipid levels and coronary artery disease.

  28167353   Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants.

  28379035   Polygenic hypercholesterolemia: examples of GWAS results and their replication in the Czech-Slavonic population.

  28426714   A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death.

  28577571   Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.

  28705542   Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease.

  29356453   Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes.