SNP information rs12740374

Research and publications:

  17634449   Genomewide association analysis of coronary artery disease.

  18262040   LDL-cholesterol concentrations: a genome-wide association study.

  19060906   Common variants at 30 loci contribute to polygenic dyslipidemia.

  19198609   Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

  19299407   Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample

  19822575   Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

  19913121   Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

  19919681   Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

  19951432   Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease

  20686566   From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

  20838585   Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.

  20839009   Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica.

  21087763   Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

  21347282   Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

  21369780   Genome-wide association studies in atherosclerosis.

  21466885   Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.

  21637794   Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.

  21829380   Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.

  21860704   Implications of discoveries from genome-wide association studies in current cardiovascular practice.

  21862702   Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.

  22022282   A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.

  22144573   Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

  22269347   Transcriptional enhancers in development and disease.

  22275870   Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.

  22539988   Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study.

  22629316   Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

  22972380   Investigation of genetic risk factors for chronic adult diseases for association with preterm birth

  23067240   Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels.

  23236364   Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.

  23723249   GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications.

  23964269   The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.

  24205329   Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data.

  24661571   Laying a strong foundation for Manhattan—“laying a functional foundation for the post-GWAS era.”

  25430627   A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake.

  25542012   Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

  26210163   Removing reference mapping biases using limited or no genotype data identifies allelic differences in protein binding at disease-associated loci.

  26249223   Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases.

  26690388   Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.

  26719772   Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome.

  26751575   Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.

  26892960   From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease.

  26958643   Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.

  28082259   Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities).

  28209224   Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

  28257648   Genetic determinants of clinical heterogeneity of the coronary artery disease in the population of Hyderabad, India.

  28388431   Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

  28577571   Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.

  29097363   Interrogation of the Atherosclerosis-Associated SORT1 (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.

  29356453   Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes.

  29973585   Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

  30065929   Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.

  32620998   Genetically programmed changes in transcription of the novel progranulin regulator.

  33235484   Influence of PSRC1, CELSR2, and SORT1 Gene Polymorphisms on the Variability of Warfarin Dosage and Susceptibility to Cardiovascular Disease.